Malaria Journal | |
The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi, Tanzania | |
Research | |
Daniel Chandramohan1  Gibson Kibiki2  Ramadhani Hashim3  Jacklin F Mosha4  Hugh JW Sturrock5  Roland D Gosling5  Joelle M Brown6  | |
[1] Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK;Kilimanjaro Clinical Research Institute and Kilimanjaro Christian Medical College, Kilimanjaro, Moshi, Tanzania;Mwanza Intervention Trials Unit, Mwanza, Tanzania;National Institute for Medical Research (NIMR), Mwanza Medical Research Centre, Mwanza, Tanzania;The Global Health Group, University of California, San Francisco, CA, USA;The Global Health Group, University of California, San Francisco, CA, USA;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; | |
关键词: Malaria; Transmission; Hotspots; Risk factor; Serology; PCR; Africa; Plasmodium falciparum; | |
DOI : 10.1186/1475-2875-13-445 | |
received in 2014-07-28, accepted in 2014-11-10, 发布年份 2014 | |
来源: Springer | |
【 摘 要 】
BackgroundAs malaria transmission declines, continued improvements of prevention and control interventions will increasingly rely on accurate knowledge of risk factors and an ability to define high-risk areas and populations at risk for focal targeting of interventions. This paper explores the independent association between living in a hotspot and prospective risk of malaria infection.MethodsMalaria infection status defined by nPCR and AMA-1 status in year 1 were used to define geographic hotspots using two geospatial statistical methods (SaTScan and Kernel density smoothing). Other malaria risk factors for malaria infection were explored by fitting a multivariable model.ResultsThis study demonstrated that residing in infection hotspot of malaria transmission is an independent predictor of malaria infection in the future.ConclusionIt is likely that targeting such hotspots with better coverage and improved malaria control strategies will result in more cost-efficient uses of resources to move towards malaria elimination.
【 授权许可】
CC BY
© Mosha et al.; licensee BioMed Central Ltd. 2014
【 预 览 】
Files | Size | Format | View |
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RO202311103033838ZK.pdf | 278KB | download |
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