CD40 mutant expression and its clinical significance to prognosis in gastric cancer patients

World Journal of Surgical Oncology

Research

Jun Wu¹  Hong-Bing Shi¹  Xiao-Dong Li¹  Mei Ji¹  Jie-Min Zhao¹  Wei-Qing Zhao¹  Chang-Ping Wu² 

[1] Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People’s Republic of China;Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People’s Republic of China;Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People’s Republic of China;

关键词: Gastric cancer;    CD40 mutant;    Immunohistochemistry;   

DOI  :  10.1186/1477-7819-12-167

 received in 2014-03-19, accepted in 2014-05-06,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWe aimed to detect CD40 mutant expression and evaluate its clinical significance in gastric cancer.MethodsCD40 mutant expression in 78 cases of gastric cancer tissues, 10 cases of normal gastric tissues, and 10 cases of gastric adenoma tissues by immunohistochemical test. Survival analyses were also performed.ResultsThe positive CD40 mutant rate in gastric cancer was 55.1% (43/78). No positive CD40 mutant staining was observed in the normal gastric tissue or the gastric adenoma. CD40 mutants expression was significantly correlated with invasive depth, lymph metastasis, and TNM stage (P <0.05). Cases with negative CD40 mutant expression had a significantly longer median survival time than those with positive CD40 mutant expression (40 vs. 14 months, P <0.05). A lower death risk in negative CD40 mutant cases was observed comparing with positive CD40 mutant cases.ConclusionsPositive CD40 mutant expression suggests a poorer prognosis of gastric cancer cases.

【 授权许可】

Unknown   
© Zhao et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.