Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions

Lipids in Health and Disease

Commentary

Brandon J. George¹  David B. Allison²  Lisa H. Antoine³ 

[1] Department of Biostatistics, University of Alabama at Birmingham, 35294, Birmingham, AL, USA;Nutrition Obesity Research Center and Department of Biostatistics, University of Alabama at Birmingham, Ryals Public Health Building, Room 140J, 35294, Birmingham, AL, USA;School of Public Health, University of Alabama at Birmingham, Ryals Public Health Building, Room 140J, 35294, Birmingham, AL, USA;School of Engineering, University of Alabama at Birmingham, 35294, Birmingham, AL, USA;

关键词: Statistical analyses;    Vegetable;    Fruit;    Cholesterol;    Nutrition;   

DOI  :  10.1186/s12944-016-0242-3

 received in 2014-12-03, accepted in 2016-03-21,  发布年份 2016

来源: Springer

【 摘 要 】

The article by Aiso et al. titled “Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study” does not meet the expected standards of Lipids in Health and Disease. Although the article concludes that there are some significant benefits to their komatsuna juice mixture, these claims are not supported by the statistical analyses used. An incorrect procedure was used to compare the differences in two treatment groups over time, and a large number of outcomes were tested without correction; both issues are known to produce high rates of false positives, making the conclusions of the study unjustified. The study also fails to follow published journal standards regarding clinical trial registration and reporting.

【 授权许可】

CC BY   
© Allison et al. 2016