期刊论文详细信息
Lipids in Health and Disease
Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var. perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study
Toshiko Kuwano1  Yukiko Seiyama1  Hiroko Inoue1  Izumi Aiso2 
[1] School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan;Department of Food and Nutritional Sciences and Environmental Health Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, 422–8526, Shizuoka, Japan
关键词: Metabolic syndrome;    Middle-aged men;    Serum cholesterol;    Fruit;    Vegetable;   
Others  :  800908
DOI  :  10.1186/1476-511X-13-102
 received in 2014-05-01, accepted in 2014-06-17,  发布年份 2014
PDF
【 摘 要 】

Background

Vegetables and fruits are rich in vitamins, minerals and, dietary fiber and contribute to the prevention and improvement of obesity and metabolic syndrome. However, inadequate intake of vegetable and fruit is a concern in Japan.

We therefore produced a juice mixture of fresh fruit and komatsuna (Brassica rapa L. var. perviridis: B. rapa) with the aim to investigate the effects of this juice mixture on anthropometric data, blood parameters, and dietary intake differences.

Methods

This study was performed as a single blind and randomized controlled trial. Subjects were 16 men (mean age, 46.4 ± 7.1 years), and they were divided into two groups (control group and intervention group). The intervention group consumed the juice mixture of fresh fruit and B. rapa. The control group consumed commercial vegetable juice. Subjects consumed juice twice a day throughout the weekday, for 4 weeks. We prepared both juices with an equivalent energy balance.

Results

Weight and body mass index (BMI) of the control group after 4 weeks were significantly increased compared with baseline values. Serum total cholesterol (T-Chol) and low-density lipoprotein cholesterol (LDL-Chol) of the intervention group after 4 weeks were significantly reduced compared with baseline values. Furthermore, intake of total vegetables and fruits were significantly increased compared with baseline values in both groups.

Conclusions

Both vegetable juices contributed to improved intake of total vegetables and fruit. Compared with the intake of commercial vegetable juice, the intake of fresh fruit and B. rapa juice is highly effective in reducing serum cholesterol. Short-term intake of fresh fruit and B. rapa juice was shown to enhance cholesterol metabolism.

【 授权许可】

   
2014 Aiso et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140708001414477.pdf 367KB PDF download
Figure 1. 50KB Image download
【 图 表 】

Figure 1.

【 参考文献 】
  • [1]Asia Pacific Cohort Studies Collaboration: Cholesterol, diabetes and major cardiovascular diseases in the Asia-Pacific region. Diabetologia 2007, 50:2289-2297.
  • [2]Guimarães PR, Galvão AM, Batista CM, Azevedo GS, Oliveira RD, Lamounier RP, Freire N, Barros AM, Sakurai E, Oliveira JP, Vieira EC, Alvarez-Leite JI: Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects. Braz J Med Biol Res 2000, 33:1027-1036.
  • [3]Djousse L, Arnett DK, Coon H, Province MA, Moore LL, Ellison RC: Fruit and vegetable consumption and LDL cholesterol: the National Heart, Lung, and Blood Institutte Family Heart Study. Am J Clin Nutr 2004, 79:213-217.
  • [4]Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Les Chik-Bonnet E, Müller MJ, Oberritter H, Schulze M, Stehle P, Watzl B: Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 2012, 51:637-663.
  • [5]Bazzano LA, He J, Ogden LG, Loria CM, Vupputuri S, Myers L, Whelton PK: Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clin Nutr 2002, 76:93-99.
  • [6]The Ministry of Health, Labor and Welfare: Health Japan 21. http://www.dietitian.or.jp/english/images/health_japan21.pdf webcite
  • [7]Shenoy SF, Kazaks AG, Holt RR, Chen HJ, Winters BL, Khoo CS, Poston WS, Haddock CK, Reeves RS, Foreyt JP, Gershwin ME, Keen CL: The use of a commercial vegetable juice as a practical means to increase vegetable intake. Nutr J 2010, 9:38. BioMed Central Full Text
  • [8]Shenoy SF, Poston WS, Reeves RS, Kazaks AG, Holt RR, Keen CL, Chen HJ, Haddock CK, Winters BL, Khoo CS, Foreyt JP: Weight loss in individuals with metabolic syndrome given DASH diet counseling when provided a low sodium vegetable juice: a randomized controlled trial. Nutr J 2010, 9:8. BioMed Central Full Text
  • [9]Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W: Effects of a flavonoid-rich juice on inflammation, oxidative stress, and immunity in elite swimmers: a metabolomics-based approach. Int J Sport Nutr Exerc Metab 2013, 23:150-160.
  • [10]Potter AS, Foroudi S, Stamatikos A, Patil BS, Deyhim F: Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults. Nutr J 2011, 10:96. BioMed Central Full Text
  • [11]Tiwari AK, Reddy KS, Radhakrishnan J, Kumar DA, Zehra A, Agawane SB, Madhusudana K: Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats. Food Funct 2011, 2:521-528.
  • [12]Suido H, Tanaka T, Tabei T, Takeuchi A, Okita M, Kishimoto T, Kasayama S, Higashino K: A mixed green vegetable and fruit beverage decreased the serum level of low-density lipoprotein cholesterol in hypercholesterolemic patients. J Agric Food Chem 2002, 50:3346-3350.
  • [13]Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J: Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. J Biol Chem 2004, 279:7521-7529.
  • [14]Fan J, Unoki H, Kojima N, Sun H, Shimoyamada H, Deng H, Okazaki M, Shikama H, Yamada N, Watanabe T: Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 2001, 276:40071-40079.
  • [15]Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008, 359:2195-2207.
  • [16]Itoh K, Kawasaka T, Nakamura M: The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects. Br J Nutr 1997, 78:737-750.
  • [17]Fuhrman B, Elis A, Aviram M: Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem Biophys Res Commun 1997, 233:658-662.
  • [18]Moreno FS, Rossiello MR, Manjeshwar S, Nath R, Rao PM, Rajalakshmi S, Sarma DS: Effect of beta-carotene on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver. Cancer Lett 1995, 96:201-208.
  • [19]Sasaki S, Ushio F, Amano K, Morihara M, Todoriki O, Uehara Y, Toyooka E: Serum biomarker-based validation of a self-administered diet history questionnaire for Japanese subjects. J Nutr Sci Vitaminol 2000, 46:285-296.
  • [20]Kobayashi S, Murakami K, Sasaki S, Okubo H, Hirota N, Notsu A, Fukui M, Date C: Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutr 2011, 14:1200-1211.
  • [21]Kobayashi S, Honda S, Murakami K, Sasaki S, Okubo H, Hirota N, Notsu A, Fukui M, Date C: Both comprehensive and brief self-administered diet history questionnaires satisfactorily rank nutrient intakes in Japanese adults. J Epidemiol 2012, 22:151-159.
  • [22]Ministry of Health, Labour and Welfare: Sanitary management of large scale cooking facilities manual (in Japanese). http://www.mhlw.go.jp/topics/syokuchu/01.html webcite
  • [23]Murata A: Plasma vitamin C concentrations of Japanese (in Japanese). Vitamins 2006, 80:513-515.
  • [24]Murata A, Ishimatsu H, Uchi Y, Kang YC, Kato F: Determination of vitamin C by the α, α’-dipyridyl method (in Japanese). Bull Fac Agr Saga Univ 1986, 61:9-19.
  文献评价指标  
  下载次数:21次 浏览次数:30次