The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Respiratory Research

Review

Clara E. Green¹  Alice M. Turner¹ 

[1] Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK;

关键词: Chronic obstructive pulmonary disease;    Emphysema;    Chronic bronchitis;    Asthma;    Endothelium;    Endothelial dysfunction;   

DOI  :  10.1186/s12931-017-0505-1

 received in 2016-10-05, accepted in 2017-01-13,  发布年份 2017

来源: Springer

【 摘 要 】

COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.

【 授权许可】

CC BY   
© The Author(s). 2017