Prevalence of chronic kidney disease in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

BMC Pulmonary Medicine

Research Article

Sameer K. Gunukula¹  James W. Lohr²  Swarna Gaddam²  Pradeep Arora³ 

[1] Department of Medicine, SUNY, Buffalo, NY, USA;Division of Nephrology at VAMC, Buffalo, NY, USA;Department of Medicine, SUNY, Buffalo, NY, USA;Division of Nephrology at VAMC, Richmond, VA, USA;Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA;

关键词: Chronic obstructive pulmonary disease;    Emphysema;    Chronic bronchitis;    Chronic kidney disease;    Comorbidity;    Glomerular filtration rate;   

DOI  :  10.1186/s12890-016-0315-0

 received in 2016-07-01, accepted in 2016-11-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe incidence and prevalence of chronic kidney disease (CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and cigarette smoking are well-recognized risk factors for CKD. Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation leading to airway obstruction and parenchymal lung destruction. Due to some of the common pathogenic mechanisms, COPD has been associated with increased prevalence of CKD.MethodsSystematic review of medical literature reporting the incidence and prevalence of CKD in patients with COPD using the Cochrane Collaboration Methodology, and conduct meta-analysis to study the cumulative effect of the eligible studies. We searched Medline via Ovid, PubMed, EMBASE and ISI Web of Science databases from 1950 through May, 2016. We included prospective and retrospective observational studies that reported the prevalence of CKD in patients with COPD.ResultsOur search resulted in 19 eligible studies of which 9 have been included in the meta-analysis. The definition of CKD was uniform across all the studies included in analysis. COPD was found to be associated with CKD in the included epidemiological studies conducted in many countries. Our meta-analysis showed that COPD was found to be associated with a significantly increased prevalence of CKD (Odds Ratio [OR] = 2.20; 95% Confidence Interval [CI] 1.83, 2.65). Study limitations: Studies included are observational studies. However, given the nature of our research question there is no possibility to perform a randomized control trial.ConclusionsPatients with COPD have increased odds of developing CKD. Future research should investigate the pathophysiological mechanism behind this association, which may lead to better outcomes.

【 授权许可】

CC BY   
© The Author(s). 2016