Penile metastasis from primary cholangiocarcinoma: the first case report

BMC Gastroenterology

Case Report

Domenico De Santis¹  Piero Maceroni¹  Giorgia Manfredonia¹  Simone Ferretti¹  Domenico Alvaro²  Carlo Della Rocca³  Claudio Di Cristofano³  Natale Porta³  Vincenzo Petrozza³  Cristina Maggioni⁴  Davide Moschese⁴  Antonio Carbone⁴  Andrea Fuschi⁴  Yazan Al Salhi⁴  Giovanni Palleschi⁴  Antonio Luigi Pastore⁴ 

[1] CADI, Radiology Department, Sapienza University of Rome, ICOT Latina, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Gastroenterology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Urology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy;

关键词: Cholangiocarcinoma;    Elastography;    Magnetic resonance;    Penile metastases;   

DOI  :  10.1186/1471-230X-13-149

 received in 2013-05-02, accepted in 2013-10-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundMetastatic penile carcinoma derived from cholangiocarcinoma (CCA) has not been previously reported in the literature. Common metastatic sites for CCA include the regional lymph nodes and adjacent organs. CCAs are not highly vascularised tumours, making hematogenous metastases uncommon. Hematogenous CCA metastases commonly occur at distant organs such as the lungs, adrenal glands, and bones. Median survival for patients with metastatic disease is generally less than 1 year.Case presentationA 74-year-old Caucasian man consulted us after having undergone penile ultrasonography for pain and increased thickness at the base of the penis after self-examination. The patient presented with a history of hepatitis C-related cirrhosis and intrahepatic CCA, diagnosed 3 years previously. A biopsy of the corpora cavernosa on both sides revealed a carcinoma harbouring the same histological and immunophenotypical features as the primary hepatic lesion.ConclusionsTo date, there is no case of penile or urogenital system metastasis from CCA described in the literature. Therefore, this article represents the first case report of penile metastasis from CCA.

【 授权许可】

CC BY   
© Pastore et al.; licensee BioMed Central Ltd. 2013