Penile metastasis from primary cholangiocarcinoma: the first case report

BMC Gastroenterology

Antonio Carbone⁴  Vincenzo Petrozza²  Davide Moschese⁴  Cristina Maggioni⁴  Yazan Al Salhi⁴  Andrea Fuschi⁴  Carlo Della Rocca²  Claudio Di Cristofano²  Natale Porta²  Simone Ferretti¹  Domenico De Santis¹  Domenico Alvaro³  Piero Maceroni¹  Giorgia Manfredonia¹  Giovanni Palleschi⁴  Antonio Luigi Pastore⁴ 

[1] CADI, Radiology Department, Sapienza University of Rome, ICOT Latina, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Gastroenterology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Urology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy

关键词: Penile metastases;    Magnetic resonance;    Elastography;    Cholangiocarcinoma;   

Others  :  857550
DOI  :  10.1186/1471-230X-13-149

 received in 2013-05-02, accepted in 2013-10-05,  发布年份 2013

【 摘 要 】

Background

Metastatic penile carcinoma derived from cholangiocarcinoma (CCA) has not been previously reported in the literature. Common metastatic sites for CCA include the regional lymph nodes and adjacent organs. CCAs are not highly vascularised tumours, making hematogenous metastases uncommon. Hematogenous CCA metastases commonly occur at distant organs such as the lungs, adrenal glands, and bones. Median survival for patients with metastatic disease is generally less than 1 year.

Case presentation

A 74-year-old Caucasian man consulted us after having undergone penile ultrasonography for pain and increased thickness at the base of the penis after self-examination. The patient presented with a history of hepatitis C-related cirrhosis and intrahepatic CCA, diagnosed 3 years previously. A biopsy of the corpora cavernosa on both sides revealed a carcinoma harbouring the same histological and immunophenotypical features as the primary hepatic lesion.

Conclusions

To date, there is no case of penile or urogenital system metastasis from CCA described in the literature. Therefore, this article represents the first case report of penile metastasis from CCA.

【 授权许可】

   
2013 Pastore et al.; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

• [1]Charbel H, Al-Kawas FH: Cholangiocarcinoma: epidemiology, risk factors, pathogenesis, and diagnosis. Curr Gastroenterol Rep 2011, 13(2):182-187.
• [2]Chindaprasirt J, Sookprasert A, Sawanyawisuth K, Limpawattana P, Tiamkao S: Brain metastases from cholangiocarcinoma: a first case series in Thailand. Asian Pac J Cancer Prev 2012, 13(5):1995-1997.
• [3]Tyson GL, El-Serag HB: Risk factors for cholangiocarcinoma. Hepatology 2011, 54(1):173-184.
• [4]Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD: Cholangiocarcinoma. Lancet 2005, 366(9493):1303-1314.
• [5]Kidambi T, Mahajan A, DiBardino D: Cholangiocarcinoma presenting as metastases to the cervical spine. Am J Med 2011, 24:1-2.
• [6]Li J, Henry MR, Roberts LR: Rare distant skeletal metastasis from hilar cholangiocarinoma: report of a case. J Gastrointest Cancer 2011, 42:171-173.
• [7]Park MH, Cho JS, Lee JS, Kim HK, Yoon JH: Thyroid gland metastasis arising from primary liver cholangiocarcinoma: The first case report involving surgical operation. Int J Surg Case Rep 2012, 3:78-81.
• [8]Alpini G, Invernizzi P, Gaudio E, Venter J, Kopriva S, Bernuzzi F, Onori P, Franchitto A, Coufal M, Frampton G, Alvaro D, Lee SP, Marzioni M, Benedetti A, DeMorrow S: Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. Cancer Res 2008, 68(22):9184-9193.
• [9]Onori P, Wise C, Gaudio E, Franchitto A, Francis H, Carpino G, Lee V, Lam I, Miller T, Dostal DE: Glaser ¨ Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptorInt J. Cancer 2010, 127(1):43-54.
• [10]Chaux A, Amin M, Cubilla AL, Young RH: Metastatic tumors to the penis: a report of 17 cases and review of the literature. Int J Surg Pathol 2011, 19(5):597-606.