Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

Malaria Journal

Research

Myo Thant¹  Tin Maung Hlaing¹  Naing Zin Aung²  Myo Thiha Zaw³  Liwang Cui⁴  Ingrid Felger⁵  Wang Nguitragool⁶  Jaranit Kaewkungwal⁷  Min Thu⁸  Kanit Phumchuea⁹  Kanokwan Phusri⁹  Teerawat Saeseu⁹  Jetsumon Sattabongkot⁹  Ritthideach Yorsaeng^1,10 

[1] Defence Services Medical Research Centre (DSMRC), Nay Pyi Taw, Myanmar;Defence Services Medical Research Centre (DSMRC), Nay Pyi Taw, Myanmar;Loikaw Military Hospital, Loikaw, Kayah, Myanmar;Defence Services Medical Research Centre (DSMRC), Nay Pyi Taw, Myanmar;Mahidol Vivax Research Unit (MVRU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Department of Entomology, The Pennsylvania State University, 501 ASI Building, 16801, University Park, PA, USA;Department of Medical Parasitology and Infection Biology, Swiss Tropical & Public Health Institute, Basel, Switzerland;Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Loikaw Military Hospital, Loikaw, Kayah, Myanmar;Mahidol Vivax Research Unit (MVRU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Mahidol Vivax Research Unit (MVRU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;

关键词: Asymptomatic;    Sub-microscopic;    Malaria;    Myanmar;   

DOI  :  10.1186/s12936-017-1789-9

 received in 2017-02-06, accepted in 2017-03-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMyanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination.MethodsA mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored.ResultsThe prevalence of asymptomatic Plasmodium spp. infection was 2.3% (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7% (8/11) and Plasmodium falciparum for 27.3% (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection.ConclusionA combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.

【 授权许可】

CC BY   
© The Author(s) 2017