Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes

Cardiovascular Diabetology

Research

Adriana Polańska¹  Ryszard Żaba¹  Aleksandra Dańczak-Pazdrowska²  Piotr Fichna³  Andrzej Kędzia³  Klaudia Bogusz-Górna³  Marta Sumińska³ 

[1] Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland;Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland;Department of Pediatric Diabetes, Auxology, and Obesity, Poznan University of Medical Sciences, Poznan, Poland;

关键词: Type 1 diabetes;    Complications;    Microangiopathy;    Microcirculation;    Capillaroscopy;    Photoplethysmography;   

DOI  :  10.1186/s12933-023-02031-y

 received in 2023-07-08, accepted in 2023-10-12,  发布年份 2023

来源: Springer

【 摘 要 】

Aims/HypothesisThe study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes.MethodsOne hundred sixty children and adolescents aged 6–18, 125 patients with type 1 diabetes, and 35 healthy volunteers were enrolled in the study. We performed a detailed clinical evaluation, anthropometric measurements, nailfold capillaroscopy, and photoplethysmography.ResultsPatients with diabetes had more often abnormal morphology in capillaroscopy (68.60%, p = 0.019), enlarged capillaries (32.6%, p = 0.006), and more often more over five meandering capillaries (20.90%, p = 0.026) compared to healthy controls. Meandering capillaries correlated with higher parameters of nutritional status. In a photoplethysmography, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves (p < 0.001) with a reduced frequency of normal curves (p = 0.050).ConclusionsCapillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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