Relationship between bladder cancer and total fluid intake: a meta-analysis of epidemiological evidence

World Journal of Surgical Oncology

Research

Yin Tang¹  Haichao Yuan¹  Ping Han¹  Yunjin Bai¹  Jinhong Li¹  Chunxiao Pu¹ 

[1] Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, 610041, Chengdu, Sichuan, China;

关键词: Bladder neoplasms;    Fluid consumption;    Etiology;    Meta-analysis;   

DOI  :  10.1186/1477-7819-12-223

 received in 2014-03-23, accepted in 2014-07-04,  发布年份 2014

来源: Springer

【 摘 要 】

ObjectivesEpidemiological findings regarding the association between total fluid intake and bladder cancer risk have yielded varying results. Our objective is to examine the possible associations between total fluid intake and bladder cancer risk.MethodsDatabases searched include the EMBASE and PUBMED, from inception to February 2014, with no limits on study language. We also reviewed the reference lists of identified studies. Stratified analyses were performed. A random-effect model was used to summarize the estimates of odds ratio (OR) with 95% confidence intervals (CI).ResultsOverall,17 case-control and four cohort studies were included. The overall OR of bladder cancer for the highest versus the lowest fluid intake was 1.06 (95% CI: 0.88-1.27). In the subgroup analyses, the overall ORs for coffee, green, and black tea intake were 1.17 (95% CI: 1.03-1.33), 0.76 (95% CI: 0.66-0.95), and 0.80 (95% CI: 0.65-0.97), respectively. A significantly decreased risk was observed in Asian people (OR 0.27; 95% CI: 0.10-0.72). Among smokers, a suggestive inverse association was observed between total fluid intake and overall bladder cancer risk (OR 0.80; 95% CI: 0.62-1.02).ConclusionsAlthough this meta-analysis suggested that greater consumption of fluid may have a protective effect on bladder cancer in Asian people, there was no convincing evidence on this association because of the limitations of the individual trials.

【 授权许可】

Unknown   
© Bai et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.