Effects of genetic variations in the Adiponectin pathway genes on the risk of colorectal cancer in the Chinese population

BMC Medical Genetics

Research Article

Zhenlin Nie¹  Bangshun He¹  Yeqiong Xu¹  Shukui Wang¹  Yuqin Pan¹  Ying Zhang²  Qian Bao³  Ling Gu³  Liping Chen³ 

[1] The Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing, Jiangsu Province, China;The Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing, Jiangsu Province, China;Clinical Laboratory, Traditional Chinese Medicine Hospital of Kunshan, 215300, Kunshan, Jiangsu Province, China;The Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing, Jiangsu Province, China;Department of Life Sciences, Nanjing Normal University, 210046, Nanjing, Jiangsu Province, China;

关键词: Colorectal cancer;    Polymorphism;    ADIPOQ;    ADIPOR;    Genetic susceptibility;   

DOI  :  10.1186/1471-2350-12-94

 received in 2010-12-20, accepted in 2011-07-12,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundDecreased expression of adiponectin (ADIPOQ) is associated with an increased risk for developing colorectal cancer (CRC) in humans. This study was designed to determine whether polymorphisms present in the ADIPOQ and its type 1 receptor (ADIPOR1) could affect the risk of CRC.MethodsWe measured five polymorphisms in the ADIPOQ and two polymorphisms in ADIPOR1, and analyzed their associations with CRC risk in 420 CRC patients and 555 age- and gender-matched healthy individuals.ResultsMultivariate logistic regression analyses revealed that the CRC risks (adjusted odds ratio and 95% confidence interval) associated with the ADIPOR1 genotypes were 0.53 (95% CI, 0.35-0.81) for rs12733285C/T, 0.59 (95% CI, 0.45-0.78) for rs1342387A/G, and 0.59 (95% CI, 0.39-0.89) for rs1342387A/A, respectively. Furthermore, the risks were more significant in carriers of the allele A of rs1342387A/G (adjusted OR, 0.59; 95% CI, 0.46-0.77) than noncarriers (G/G). In a further subgroup analysis, we observed that rs266729G/C was associated with an increased risk for colon cancer (adjusted OR, 1.50; 95% CI, 1.05-2.14) but not for rectal cancer (adjusted OR, 0.88; 95% CI, 0.63-1.22), and that carriers of the G allele had an increased risk for developing colon cancer (adjusted OR, 1.45; 95% CI, 1.03-2.05).ConclusionsWe conclude that the rs12733285C/T genotype and the carriage of the A allele of rs1342387 (A/G or A/A) in ADIPOR1 are the protective factors for CRC, while that rs266729G/C and G allele of ADIPOQ are the risk factors for colon cancer after excluding rectal cancer cases.

【 授权许可】

Unknown   
© He et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.