Elevated serum fibroblast growth factor 23 levels as an indicator of lower extremity atherosclerotic disease in Chinese patients with type 2 diabetes mellitus

Cardiovascular Diabetology

Original Investigation

Xiang Hu¹  Jian Zhou¹  Hang Su¹  Lingwen Ying¹  Jiahui Peng¹  Xiaojing Ma¹  Xiaoping Pan¹  Xingxing He¹  Weiping Jia¹  Yuqian Bao¹ 

[1] Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, 200233, Shanghai, China;

关键词: Type 2 diabetes mellitus;    Lower extremity atherosclerotic disease;    Fibroblast growth factor 23;    Femoral intima-media thickness;   

DOI  :  10.1186/s12933-017-0559-x

 received in 2017-03-31, accepted in 2017-06-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundRecently, basic and clinical studies have provided evidence supporting the relationship between circulating levels of fibroblast growth factor (FGF) 23 and the development of atherosclerosis. Given that diabetes is an established risk factor for lower extremity atherosclerotic disease (LEAD), the goal of the present study was to explore the relationship between serum FGF23 levels and LEAD, as well as the related factors, in Chinese patients with type 2 diabetes mellitus (T2DM).MethodsA total of 401 hospitalized T2DM patients (201 subjects with LEAD and 200 subjects without LEAD) were enrolled in this study. Serum FGF23 levels were determined by a sandwich enzyme-linked immunosorbent assay. Femoral intima-media thickness (F-IMT) and lower limb atherosclerotic plaque were assessed through color Doppler ultrasound.ResultsThe median (interquartile range) serum FGF23 levels in the entire study population was 42.08 (35.59–49.17) pg/mL. Subjects with LEAD had significantly higher serum FGF23 levels compared with those without LEAD (44.00 [37.54–51.30] pg/mL versus 40.42 [32.61–48.23] pg/mL, P < 0.001). Logistic regression showed that serum FGF23 levels were independently and positively correlated with the presence of LEAD (odds ratio 1.039, 95% confidence interval 1.012–1.067, P = 0.004). In addition, multiple liner regression analysis revealed that serum FGF23 levels were positively associated with F-IMT (standardized β = 0.175, P < 0.001). Furthermore, this relationship remained significant after additional adjustment for gender and factors potentially affecting serum FGF23 levels (serum calcium, serum phosphorus, and glomerular filtration rate), respectively (both P < 0.01).ConclusionsIn Chinese patients with T2DM, serum FGF23 levels were independently and positively correlated with the presence of LEAD.

【 授权许可】

CC BY   
© The Author(s) 2017