C-Terminal to Intact Fibroblast Growth Factor 23 Ratio in Relation to Estimated Glomerular Filtration Rate in Elderly Population

Kidney and Blood Pressure Research

Kocełak P.³  Owczarek A.¹  Olszanecka-Glinianowicz M.³  Chudek J.²  Bożentowicz-Wikarek M.²  Więcek A.¹ 

[1] Pathophysiology Unit, Department of Pathophysiology, Faculty of Medicine in Katowice; $$;Health Promotion and Obesity Management Unit, Department of Pathophysiology; $$

关键词: Chronic kidney disease;    Elderly population;    Fibroblast growth factor 23;   

DOI  :  10.1159/000443452

来源: S Karger AG

【 摘 要 】

Background/Aims: An analytical equivalence between intact fibroblasts growth factor(iFGF23) and C-terminal(cFGF23) assays is logically expected, however, numerous studies demonstrate lack of a strong association between them. Previously, we have demonstrated the increase in cFGF23 slightly precedes the increase of iFGF23 with the impairment of kidney excretory function; without actually analyzing the ratio between both assays, which are postulated to be affected by declining kidney function. Therefore, the aim of this study was to analyze the ratio between C and iFGF23 in relation to the estimated glomerular filtration rate (eGFR) in an elderly population. Methods: We analysed the variability of c/iFGF23 ratio in the population of 3264 elderly PolSenior study participants (≥ 65years) in the relation to eGFR calculated according full Modification of Diet in Renal Disease, serum levels of C-reactive protein (hs-CRP), and iron. Results: The log₁₀(c/i FGF23 ratio) increased in the subsequent CKD stages. Serum iron and CRP levels reduced the log₁₀ and increased it with age in multivariate regression analysis. Conclusions: Our results suggest impairment in the cleavage of the C-terminal FGF23 fragments with the deterioration of kidney excretory function and age in the elderly population. Inflammation and low serum iron level seems to diminish degradation capacity of FGF23 fragments.

【 授权许可】

Unknown