Detection of quantitative trait loci affecting haematological traits in swine via genome scanning

BMC Genetics

Research Article

Fang Hu¹  Xiao-Yan Niu¹  Yan-Ru Luo¹  Zhi-Peng Wang¹  Shao-Qian Cai¹  Jian Zeng¹  Chun-Mei Qi¹  Shan Li¹  Qin Zhang¹  Xiao-Tian Qiu¹  Yuan-Fang Gong²  Xin Lu³ 

[1] Key Laboratory Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China;Key Laboratory Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China;Department of Animal Science, Hebei Normal University of Science & Technology, 066600, Chang li, Hebei, China;Key Laboratory Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China;National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, 102206, Changping, Beijing, China;

关键词: False Discovery Rate;    Mapping Population;    Hemocyte;    Mean Platelet Volume;    Mean Corpuscular Volume;   

DOI  :  10.1186/1471-2156-11-56

 received in 2009-11-03, accepted in 2010-06-28,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundHaematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especially in swine.ResultsIn the present study, 18 haematological traits (7 leukocyte traits, 7 erythrocyte traits and 4 platelet traits) were measured in a pig resource population consisting of 368 purebred piglets of three breeds (Landrace, Large White and Songliao Black Pig), after inoculation with the swine fever vaccine when the pigs were 21 days old. A whole-genome scan of QTL for these traits was performed using 206 microsatellite markers covering all 18 autosomes and the X chromosome. Using variance component analysis based on a linear mixed model and the false discovery rate (FDR) test, 35 QTL with FDR < 0.10 were identified: 3 for the leukocyte traits, 28 for the erythrocyte traits, and 4 for the platelet traits. Of the 35 QTL, 25 were significant at FDR < 0.05 level, including 9 significant at FDR < 0.01 level.ConclusionsVery few QTL were previously identified for hematological traits of pigs and never in purebred populations. Most of the QTL detected here, in particular the QTL for the platelet traits, have not been reported before. Our results lay important foundation for identifying the causal genes underlying the hematological trait variations in pigs.

【 授权许可】

Unknown   
© Gong et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.