Microbial production of hyaluronic acid: current state, challenges, and perspectives

Microbial Cell Factories

Review

Guocheng Du¹  Yanfeng Liu¹  Long Liu¹  Jianghua Li¹  Jian Chen² 

[1] Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China;School of Biotechnology, Jiangnan University, 214122, Wuxi, China;State Key Laboratory of Food Science and Technology, Jiangnan University, 214122, Wuxi, China;

关键词: Hyaluronic acid;    Streptococcus zooepidemicus;    Metabolic engineering;    Molecular weight;   

DOI  :  10.1186/1475-2859-10-99

 received in 2011-07-20, accepted in 2011-11-16,  发布年份 2011

来源: Springer

【 摘 要 】

Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals.Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.

【 授权许可】

Unknown   
© Liu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.