Regulation of lipid droplet turnover by ubiquitin ligases

BMC Biology

Commentary

Philipp Alberts¹  Daniela Rotin¹ 

[1]Cell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, M5G 1L7, Toronto, Ontario, Canada

关键词: Lipid Droplet;    Ubiquitin Ligase;    Lipid Body;    Hereditary Spastic Paraplegia;    HECT Domain;   

DOI  :  10.1186/1741-7007-8-94

 received in 2010-06-02, accepted in 2010-07-05,  发布年份 2010

来源: Springer

【 摘 要 】

Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate.See research article: http://www.biomedcentral.com/1741-7007/8/72/

【 授权许可】

CC BY   
© Alberts and Rotin; licensee BioMed Central Ltd. 2010