Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae

Microbial Cell Factories

Review

Wei-Luen Yu¹  Nathan G Schoepp¹  Michael D Burkart²  William Ansari³  Michael J Hannon³  Stephen P Mayfield⁴ 

[1]Department of Chemistry & Biochemistry, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

[2]Department of Chemistry & Biochemistry, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

[3]The San Diego Center for Algae Biotechnology, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

[4]Division of Molecular Biology, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

[5]Division of Molecular Biology, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

[6]The San Diego Center for Algae Biotechnology, University of California San Diego, 500 Gilman Drive, 92093, La Jolla, CA, USA

关键词: Microalgae;    Erucic Acid;    Lipid Body;    Fatty Acid Biosynthesis;    Cetane Number;   

DOI  :  10.1186/1475-2859-10-91

 received in 2011-06-01, accepted in 2011-11-02,  发布年份 2011

来源: Springer

【 摘 要 】

Microalgae have presented themselves as a strong candidate to replace diminishing oil reserves as a source of lipids for biofuels. Here we describe successful modifications of terrestrial plant lipid content which increase overall lipid production or shift the balance of lipid production towards lipid varieties more useful for biofuel production. Our discussion ranges from the biosynthetic pathways and rate limiting steps of triacylglycerol formation to enzymes required for the formation of triacylglycerol containing exotic lipids. Secondarily, we discuss techniques for genetic engineering and modification of various microalgae which can be combined with insights gained from research in higher plants to aid in the creation of production strains of microalgae.

【 授权许可】

Unknown   
© Yu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.