The relevance of non-human primate and rodent malaria models for humans

Malaria Journal

Commentary

Erica Pasini¹  Eleanor Riley²  John Harty³  Jean Langhorne⁴  Pierre Buffet⁵  Michael Good⁶  Maria M Mota⁷  Laurent Renia⁸  Patrick Duffy⁹  Didier Leroy^1,10  Monique Stins^1,11  Mary Galinski^1,12 

[1] Biomedical Primate Research Centre (BPRC), Lange Kleiweg, 161, 2288, Rijswijk, GJ, The Netherlands;Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK;Departments of Microbiology and Pathology, and Interdisciplinary Program in Immunology, Carver College of Medicine, University of Iowa, 3-530 Bowen Science Building, 51 Newton Road, 52242, Iowa City, IA, USA;Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, NW7 1AA, London, UK;Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France;Institute for Glycomics, Griffith University, G26/4.18 Gold Coast Campus, 4222, QLD, Australia;Instituto de Medicina Molecular, Unidade de Malária, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal;Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos Building, 138648, Biopolis, Singapore, Singapore;Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, 5640 Fishers Lane, 20852, Rockville, MD, USA;Medicines for Malaria Venture, ICC - Block G, PO Box 1826, 3rd Floor, 20 route de Pré-Bois, 1215, Geneva 15, Switzerland;RT Johnson Division of NeuroImmunology, Johns Hopkins School of Medicine, 1550 Orleans street, CRB II, Office Room 353/Laboratory Room 362, 21231, Baltimore, MD, USA;Yerkes National Primate Research Center, International Center for Malaria Research, Education & Development, Emory University School of Medicine, Emory University, 954 Gatewood Rd, 30329, Atlanta, GA, USA;

关键词: Malaria;    Cerebral Malaria;    Human Malaria;    Plasmodium Berghei;    Human Malaria Parasite;   

DOI  :  10.1186/1475-2875-10-23

 received in 2010-12-02, accepted in 2011-02-02,  发布年份 2011

来源: Springer

【 摘 要 】

At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material.

【 授权许可】

CC BY   
© Langhorne et al; licensee BioMed Central Ltd. 2011