Factors associated with improved survival following surgical treatment for metastatic prostate cancer in the spine: retrospective analysis of 29 patients in a single center

World Journal of Surgical Oncology

Research

Tianqi Fan¹  Jianru Xiao¹  Bo Li¹  Zhenxi Li¹  Wang Zhou¹  Nanzhe Zhong¹  Tong Meng¹  Huabin Yin²  Dianwen Song²  Rui Chen³ 

[1] Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, China;Department of Orthopedics, Shanghai Jiao Tong University, Shanghai First People’s Hospital, No. 100 Haining Road, 200080, Shanghai, China;Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, China;

关键词: Prostate cancer;    Spinal metastases;    Surgical outcomes;    Prognostic factors;    Survival analysis;   

DOI  :  10.1186/s12957-016-0961-y

 received in 2015-12-10, accepted in 2016-07-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundProstate cancer (PCa) is very common and frequently metastasizes to the spine. However, PCa spinal metastases were rarely reported in the literature. In this study, the outcome of therapies and prognostic factors affecting surgical outcomes for patients with PCa spinal metastases are discussed to select the best candidates for aggressive surgical resection.MethodsAll patients affected by the spinal metastatic PCa surgically treated at our spine tumor center were reviewed. Overall survival was analyzed from the time of spinal surgery. A univariate survival analysis and a multivariate Cox proportional hazard analysis to identify independent prognostic factors were carried out. The survival rate was estimated by the Kaplan-Meier method, and differences were analyzed by the log-rank test. Factors with P values of 0.1 or less were subjected to multivariate analysis for survival rate by multivariate Cox proportional hazard analysis.ResultsA total of 31 consecutive patients were identified. Of these, 29 underwent surgical resection. The median survival time of all patients after their spinal surgery was 44.0 months. Visceral metastases, revised Tokuhashi scores (0–8/9–11/12–15), Tomita scores (7–10/2–6), hormone status, and bisphosphonate treatment were suggested as the potential prognostic factors through univariate analysis. As they were submitted to the multivariate Cox regression model, visceral metastases and Tomita score were found as independent prognostic factors.ConclusionsPatients without visceral metastases and a Tomita score no more than 6 are favorable prognostic factors for PCa metastases in the mobile spine.

【 授权许可】

CC BY   
© The Author(s). 2016