Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic endometriosis therapy

Biomaterials Research

Research Article

Wei Tian¹  Mingjiang Li¹  Ran Chu¹  Chenyu Wang¹  Xiao Sun²  Haiyan Ge² 

[1] Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China;

关键词: Injectable hydrogels;    Controlled drug delivery;    Photothermal therapy;    Endocrine therapy;    Endometriosis;    Letrozole;   

DOI  :  10.1186/s40824-023-00442-2

 received in 2023-07-21, accepted in 2023-09-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEndometriosis is a common gynecological disease in women of childbearing age. Commonly used treatment methods, such as endocrine and surgical therapies, display poor therapeutic effects with a high relapse probability. Thus, novel treatments for endometriosis are required.MethodsIn our study, polydopamine (PDA), letrozole (LTZ), and agarose (AG) hydrogels were combined to construct an injectable hydrogel with near-infrared controlled drug delivery named LTZ-PDA@AG hydrogel for endometriosis treatment. The release of letrozole can be accurately controlled by the near-infrared light intensity, exposure duration, polydopamine concentration, and hydrogel composition. Meanwhile, we isolated endometrial stromal cells from endometrium in patients with endometriosis, and constructed the rats’ model of endometriosis to verify the biological effects of LTZ-PDA@AG hydrogel.ResultsOwing to the sufficiently deep penetration of near-infrared light, the LTZ-PDA@AG hydrogel displayed a high temperature increase for efficient photothermal therapy. In addition, high local temperatures can further enhance the diffusion and penetration of letrozole, thereby achieving excellent therapeutic effect in vivo. Importantly, the in vivo and vitro test demonstrated the capacity of the nanocomposite hydrogel for endocrine-photothermal synergistic therapy and the biocompatibility.ConclusionOur work proposes a novel concept for precision endometriosis therapy by photothermal-enhanced endocrine therapy for endometriosis, which is proposed for the first time for the treatment of endometriosis and demonstrates excellent potential for further clinical translation.Trial registrationNot applicable.Graphical AbstractLTZ-PDA@AG hydrogels were synthesized and displayed a high temperature increase for efficient photothermal therapy under NIR. The present study shows the capacity of the nanocomposite hydrogel for endocrine-photothermal synergistic therapy and the biocompatibility.

【 授权许可】

CC BY   
© The Korean Society for Biomaterials 2023

【 图 表 】

Fig. 1

12951_2016_246_Article_IEq15.gif

12951_2016_246_Article_IEq8.gif

Fig. 1

12951_2015_155_Article_IEq78.gif

12936_2015_836_Article_IEq25.gif

Fig. 6