An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall

World Journal of Surgical Oncology

Case Report

Tatsuki R Kataoka¹  Hironori Haga¹  Masahiro Hirata¹  Ayako Furuhata¹  Eiji Katsuyama²  Nobuhiro Yamashita²  Seiichi Hirota³  Takaki Ishida⁴  Ichiro Nakamura⁴ 

[1] Department of Diagnostic Pathology, Kyoto University Hospital, 606-8507, Sakyo-ku, Kyoto, Japan;Department of Pathology and Laboratory Medicine, Kobe City Medical Center West Hospital, 653-0013, Kobe, Hyogo, Japan;Department of Surgical Pathology, Hyogo College of Medicine, 663-8501, Nishinomiya, Hyogo, Japan;Department of Urology, Kobe City Medical Center West Hospital, 653-0013, Kobe, Hyogo, Japan;

关键词: Anaplastic lymphoma kinase;    Differential diagnosis;    FISH;    Gastrointestinal stromal tumor;    Inflammatory myofibroblastic tumor;    KIT;    Urinary bladder;   

DOI  :  10.1186/1477-7819-12-186

 received in 2013-08-30, accepted in 2014-06-12,  发布年份 2014

来源: Springer

【 摘 要 】

Inflammatory myofibroblastic tumors (IMTs) and gastrointestinal stromal tumors (GISTs) are both spindle cell tumors, and occur rarely in the wall of the urinary bladder. In general, immunostaining allows differentiation of IMTs and GISTs. Most IMTs are positive for anaplastic lymphoma kinase (ALK) and negative for KIT, whereas most GISTs are ALK-negative and KIT-positive. Here, we describe a case of a spindle cell tumor in the wall of the urinary bladder. The spindle cells were positive for both ALK and KIT, and it was thus difficult to determine whether the tumor was an IMT or a GIST. We eventually diagnosed an IMT, because ALK gene rearrangement was confirmed by fluorescent in-situ hybridization. Cytoplasmic staining for KIT and the absence of other GIST markers, including DOG1 and platelet-derived growth factor α, indicated that the tumor was not a GIST. Therefore, IMTs should be included in the differential diagnosis of spindle cell tumors, even those that are KIT-positive.

【 授权许可】

Unknown   
© Kataoka et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.