Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

Journal of Translational Medicine

Research

Francesca Pivari¹  Caterina Brasacchio¹  Alessandra Mingione¹  Daniele Cusi²  Elena Dogliotti³  Flavia Ricca⁴  Annalisa Terranegra⁵  Daniele Braga⁶  Erika Salvi⁶  Cristina Barlassina⁶  Martina Chittani⁶  Laura Soldati⁶  Federica Rizzi⁶  Matteo Barcella⁶  Sara Lupoli⁶  Francesca D’Avila⁶  Costanza Conti⁷  Maurizio Turiel⁸  Monica Lazzaroni⁹ 

[1] Department of Health Sciences, Università degli Studi di Milano, Via Antonio di Rudinì 8, Milan, Italy;Division of Nephrology, ASST Santi Paolo e Carlo, Via Antonio di Rudinì 8, Milan, Italy;Department of Health Sciences, Università degli Studi di Milano, Via Antonio di Rudinì 8, Milan, Italy;Institute of Biomedical Technologies, Italian National Centre of Research, Segrate, Milan, Italy;Division of Nephrology, ASST Santi Paolo e Carlo, Via Antonio di Rudinì 8, Milan, Italy;Fondazione Umberto Veronesi, Milan, Italy;Division of Nephrology, ASST Santi Paolo e Carlo, Via Antonio di Rudinì 8, Milan, Italy;Sport Medicine Division, Department of Public Health, University Federico II, Naples, Italy;Division of Translational Medicine, Sidra Medical Research Center, Doha, Qatar;Genomics and Bionformatics Unit, Department of Health Sciences, Università degli Studi di Milano, viale Ortles 22/4, Milan, Italy;Genomics and Bionformatics Unit, Department of Health Sciences, Università degli Studi di Milano, viale Ortles 22/4, Milan, Italy;Kos Genetic srl, Milan, Italy;IRCCS Galeazzi Orthopedic Institute, Via Riccardo Galeazzi, 4, Milan, Italy;Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy;

关键词: Nutrigenomics;    Lipid profile;    Anthocyanins;    Polyphenols;    HDL;    Antioxidants;    Genetic variants;    Gene diet interaction;    PON1 gene;   

DOI  :  10.1186/s12967-016-0941-6

 received in 2016-05-06, accepted in 2016-06-11,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundParaoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population.MethodsWe recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24 h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma.ResultsWithout considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p ≤ 0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta = 4.7 per C allele; rs854552, Beta = 5.6 per C allele; rs854571, Beta = 3.92 per T allele; rs854572, Beta = 3.94 per C allele).ConclusionsWe highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.

【 授权许可】

CC BY   
© The Author(s) 2016