Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans

Lipids in Health and Disease

Research

Federica Coccia¹  Frida Leonetti¹  Cristina Maglio²  Maria A Burza³  Federica Sentinelli⁴  Francesca Scano⁴  Efisio Cossu⁴  Michela Incani⁴  Marco G Baroni⁴  Stefano Romeo⁵ 

[1] Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy;Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy;Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascolar and Metabolic Research, University of Gothenburg, Sweden;Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascolar and Metabolic Research, University of Gothenburg, Sweden;Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy;Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy;Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK;Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascolar and Metabolic Research, University of Gothenburg, Sweden;

关键词: hepatic transaminases;    NAFLD;    BMI;    obesity;    tryglicerides;    HDL;    atherogenic dyslipidemia;   

DOI  :  10.1186/1476-511X-10-93

 received in 2011-05-02, accepted in 2011-06-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundApolipoprotein C3 (APOC3) is a component of triglyceride-rich lipoproteins, and APOC3 rs2854116 and rs2854117 polymorphisms have been associated with non-alcoholic fatty liver disease, hypertriglyceridaemia, and insulin-resistance.ObjectiveTo determine if the APOC3 variants alter the susceptibility of obese subjects to develop liver damage, hypertrigliceridaemia, and insulin-resistance.MethodsThe study was carried out on 585 unrelated obese Italians (median body mass index BMI = 41 kg/m2) who were genotyped for the rs2854116 and rs2854117 variants. All participants underwent oral glucose tolerance tests (OGTT), with measurement of glucose, insulin, lipid parameters. Indices of insulin-resistance (HOMA and ISI) were calculated. Alanine transaminase (ALT) and aspartate transaminase (AST) were used as markers of liver injury.ResultsThe study subjects were divided into two groups: those homozygous for the wild-type alleles at both SNPs (-482C and -455T alleles) and those who were carriers of at least one variant allele or both (-482T, -455C or both). Also each SNP was analysed independently. No significant differences were found in ALT and AST levels and in the lipid profile between the two groups. Insulin concentrations, glucose tolerance and insulin sensitivity were similar in the two groups.ConclusionWe did not identify any significant association between APOC3 polymorphisms and fatty liver disease, lipids, and insulin-resistance in obese subjects, thus not confirming the suggested role of these APOC3 gene sequence variants.

【 授权许可】

Unknown   
© Sentinelli et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.