Normal weight diabetic patients versus obese diabetics: relation of overall and abdominal adiposity to vascular health

Cardiovascular Diabetology

Original Investigation

Marina Shargorodsky¹  Alla Lukich²  Dov Gavish³ 

[1]Departments of Endocrinology, Wolfson Medical Center, POB 5, 58100, Holon, Israel

[2]Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

[3]Departments of Medicine, Wolfson Medical Center, Holon, Israel

[4]Departments of Medicine, Wolfson Medical Center, Holon, Israel

[5]Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

关键词: Body Mass Index;    Waist Circumference;    Arterial Stiffness;    Pulse Wave Velocity;    Abdominal Obesity;   

DOI  :  10.1186/s12933-014-0141-8

 received in 2014-08-07, accepted in 2014-10-05,  发布年份 2014

来源: Springer

【 摘 要 】

ObjectiveThe present study investigated the impact of overall obesity defined by BMI and abdominal obesity defined by WC on vascular atherosclerotic changes in obese and normal weight diabetic subjects.Design and methods285 subjects were divided according to presence diabetes mellitus (DM) and obesity: Group 1 included 144 nonobese subjects without DM; Group 2 consisted of 141 type 2 diabetic patients. Then diabetic patients were divided into two groups according to presence of overall obesity, defined by BMI and furthermore, abdominal obesity, defined by waist circumference (WC). Pulse wave velocity (PWV) and augmentation index (AI) were performed using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia).ResultsBetween Group Comparisons by BMI: Diabetic subjects with and without overall obesity did not differ from one another in terms of AI and PWV.Between Group Comparisons by WC: AI as well as PWV increased consistently from Group 1 to Group 3, AI and PWV were significantly higher in abdominally obese diabetic subjects than in the diabetics without abdominal obesity (p = 0.008 and p = 0.013, respectively). Significant by-group differences in PWV and AI persisted after adjustment for age, sex, blood pressure, fasting glucose and BMI.ConclusionsAbdominal obesity defined by WC was associated with significantly higher AI and PWV in in both diabetic men and women; whereas overall obesity defined by BMI did not predict adverse vascular changes in this study population. Abdominal obesity was associated with an adverse effect on blood vessels, independently of age, sex, blood pressure, fasting glucose and BMI.

【 授权许可】

CC BY   
© Shargorodsky et al.; licensee BioMed Central Ltd. 2014