Genetic variation in Tanis was associated with elevating plasma triglyceride level in Chinese nondiabetic subjects

Lipids in Health and Disease

Research

Zhen-Yan Fu¹  Ying-Ying Zheng¹  Ying Huang¹  Yi-Tong Ma¹  Yi-Ning Yang¹  Fen Liu¹  Xiang Xie¹  Xiang Ma¹  Ying Gao¹  Xiao-Mei Li¹  Bang-Dang Chen² 

[1] Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, 830011, Urumqi, P.R. China;Xinjiang Key Laboratory of Cardiovascular Disease Research, 830011, Urumqi, P.R. China;

关键词: Genetics;    Tanis;    Triglyceride;    Diabetes;    Polymorphisms;   

DOI  :  10.1186/1476-511X-12-97

 received in 2013-05-16, accepted in 2013-06-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe association of genetic polymorphisms of Tanis with triglyceride concentration in human has not been thoroughly examined. We aimed to investigate the relationship between triglyceride concentrations and Tanis genetic polymorphisms.MethodsAll participants (n=1497) selected from subjects participating in the Cardiovascular Risk Survey (CRS) study were divided into two groups according to ethnicity (Han: n=1059; Uygur: n= 438). Four tagging SNPs (rs12910524, rs1384565, rs2101171, rs4965814) of Tanis gene were genotyped using TaqMan® assays from Applied Biosystems following the manufacturer’s suggestions and analyzed in an ABI 7900HT Fast Real-Time PCR System.ResultsWe found that the SNP rs12910524 was associated with triglyceride levels by analyses of a dominant model (P<0.001), recessive model (P <0.001) and additive model (P < 0.001) not only in Han ethnic but also in Uygur ethnic group, and the difference remained significant after the adjustment of sex, age, alcohol intake, smoking, BMI and plasma glucose (GLU) level (All P < 0.001). However, this relationship was not observed in rs1384565, rs2101171, and rs4965814 before and after multivariate adjustment (All P > 0.05). Furthermore, there were significant interactions between rs12910524 and GLU on TG both in Han (P=0.001) and Uygur population (P=2.60×10-4).ConclusionOur results indicated that the rs12910524 in the Tanis gene was associated with triglyceride concentrations in subjects without diabetes in China.

【 授权许可】

Unknown   
© Gao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.