European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections

BMC Veterinary Research

Research Article

Joachim Steenbergen¹  Delphine Criel¹  Roswitha Dorsch²  Astrid M. van Dongen³  Maria Kritsepi-Konstantinou⁴  Marta Costa⁵  Els M. Broens⁶  Marloes A. M. van Dijk⁶  Peter Damborg⁷  Luca Guardabassi⁸  Domenico Mion⁹  Renato Giulio Zanoni⁹  Dusan Misic^1,10  Cátia Marques^1,11  Adriana Belas^1,11  Constança Pomba^1,11  Luís Telo Gama^1,11  Rebeca Movilla^1,12  Xavier Roura^1,12  Carmen Martin Espada^1,13  Georg Wolf^1,14  Igor Loncaric^1,15  Gudrun Overesch^1,16  Vincent Perreten^1,16  Sarah Schmitt^1,17  Alexandra Briend-Marchal^1,18  Stéphanie Beurlet^1,18  Dorina Timofte^1,19  Karin Bergström^2,20  Bernhard Gerber^2,21 

[1] AML-Medvet laboratory, Antwerp, Belgium;Clinic of Small Animal Medicine, LMU Munich, Munich, Germany;Department of Clinical Sciences of Companion Animals, University of Utrecht, Utrecht, The Netherlands;Department of Clinical Studies, Companion Animal Clinic, Faculty of Health Sciences, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;Department of Clinical Veterinary Sciences, Faculty of Medical and Veterinary Sciences, University of Bristol, Langford, UK;Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands;Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark;Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark;Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis;Department of Veterinary Medical Science, University of Bologna, Bologna, Italy;Department of microbiology, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Serbia;Faculdade de Medicina Veterinária, Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA), Lisboa, Portugal;Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain;Hospital Clínico Veterinario Complutense, Universidad Complutense, Servicio de Microbiologia y Parasitologia, Madrid, Spain;Institute for Infectious Diseases and Zoonoses, LMU Munich, Munich, Germany;Institute of Microbiology, University of Veterinary Medicine, Vienna, Austria;Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland;Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;Laboratoire Vebiotel, Arcueil, France;School of Veterinary Science, University of Liverpool, Cheshire, UK;Faculty of Veterinary Medicine, University of Agronomical Sciences Veterinary Medicine, Lasi, Romania;Institute of Infection and Global Health, University of Liverpool, Liverpool, UK;The National Veterinary Institute (SVA), Uppsala, Sweden;Vetsuisse Faculty, University of Zurich, Clinic for Small Animal Internal Medicine, Zurich, Switzerland;

关键词: Antimicrobial resistance;    Temporal trends;    MRSA;    MRSP;    Dog;    Cat;   

DOI  :  10.1186/s12917-016-0840-3

 received in 2015-09-19, accepted in 2016-09-13,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThere is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined. Samples were collected between 2008 and 2013 from 16 laboratories of 14 European countries. The prevalence of antimicrobial resistance of the most common bacteria was determined for each country individually in the years 2012–2013 and temporal trends of bacteria resistance were established by logistic regression.ResultsThe aetiology of uropathogenic bacteria differed between dogs and cats. For all bacterial species, Southern countries generally presented higher levels of antimicrobial resistance compared to Northern countries. Multidrug-resistant Escherichia coli were found to be more prevalent in Southern countries. During the study period, the level of fluoroquinolone-resistant E. coli isolated in Belgium, Denmark, France and the Netherlands decreased significantly. A temporal increase in resistance to amoxicillin-clavulanate and gentamicin was observed among E. coli isolates from the Netherlands and Switzerland, respectively. Other country-specific temporal increases were observed for fluoroquinolone-resistant Proteus spp. isolated from companion animals from Belgium.ConclusionsThis work brings new insights into the current status of antimicrobial resistance in bacteria isolated from companion animals with UTI in Europe and reinforces the need for strategies aiming to reduce resistance.

【 授权许可】

CC BY   
© The Author(s). 2016