Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

Cell Communication and Signaling

Review

Arnaud Kengmo Tchoupa¹  Tamara Schuhmacher¹  Christof R Hauck² 

[1] Lehrstuhl für Zellbiologie, Universität Konstanz, 78457, Konstanz, Germany;Lehrstuhl für Zellbiologie, Universität Konstanz, 78457, Konstanz, Germany;Konstanz Research School Chemical Biology, Universität Konstanz, 78457, Konstanz, Germany;

关键词: Signal transduction;    GPI anchor;    Membrane microdomains;    Endocytosis;    CEACAM;   

DOI  :  10.1186/1478-811X-12-27

 received in 2013-11-06, accepted in 2014-03-24,  发布年份 2014

来源: Springer

【 摘 要 】

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) comprise a group of immunoglobulin-related vertebrate glycoproteins. Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body. As they modulate diverse cellular functions, their signaling capacity is in the focus of current research. In this review we will summarize the knowledge about common signaling processes initiated by epithelial CEACAMs and suggest a model of signal transduction by CEACAM family members lacking significant cytoplasmic domains. As pathogenic and non-pathogenic bacteria exploit these receptors during mucosal colonization, we try to highlight the connection between CEACAMs, microbes, and cellular responses. Special emphasis in this context is placed on the functional interplay between CEACAMs and integrins that influences matrix adhesion of epithelial cells. The cooperation between these two receptor families provides an intriguing example of the fine tuning of cellular responses and their manipulation by specialized microorganisms.

【 授权许可】

Unknown   
© Tchoupa et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.