Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Lipids in Health and Disease

Research

Lynnda J. N. van Tienhoven-Wind¹  Robin P. F. Dullaart¹ 

[1] Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands;

关键词: Adiponectin;    Leptin;    Leptin/adiponectin ratio;    Metabolic syndrome;    Thyroid function;   

DOI  :  10.1186/s12944-016-0403-4

 received in 2016-11-10, accepted in 2016-12-27,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundLow-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown.MethodsRelationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range).ResultsNeither plasma leptin nor adiponectin was significantly correlated with TSH or free T4 in subjects with and without MetS. In the whole group, high sensitivity C-reactive protein (hs-CRP) was positively correlated with the L/A ratio (r = 0.485, P < 0.001). Notably, the L/A ratio was positively correlated with TSH in subjects with MetS (r = 0.252, P = 0.040) but not in subjects without MetS (r = −0.068, P = 0.54; interaction term, P = 0.027). In MetS subjects, the L/A ratio remained positively related with TSH after adjustment for age, sex, diabetes status, hs-CRP and the use of antihypertensive and glucose lowering medication (β = 0.283, P = 0.018), as well as after adjustment for individual MetS components (β = 0.294, P = 0.020).ConclusionsIn the context of MetS, a higher TSH within the euthyroid range confers an increased L/A ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.

【 授权许可】

CC BY   
© The Author(s). 2017