Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome

Endocrine Journal

Soyoung Won¹  Heejin Kimm¹  Sun Ha Jee¹  Wenying Cui¹  Ji Eu Yun¹  Yejin Mok¹ 

[1] Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-752, Republic of Korea

关键词: Adiponectin;    High-molecular-weight adiponectin;    Leptin;    Leptin/adiponectin ratio;    Metabolic syndrome;   

DOI  :  10.1507/endocrj.K11E-084

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(49)Cited-By(5)Recent studies have reported that leptin and adiponectin are associated with metabolic syndrome.The leptin/adiponectin ratio has been suggested as an atherosclerotic index.The objective of this study was to compare the degree of association of metabolic syndrome with adiponectin levels, leptin levels, leptin/adiponectin ratio, and leptin/high-molecular-weight (HMW) adiponectin ratio.The study population included 3272 Koreans (men: 1915, women: 1357; age, 30-84 years), who had visited the Health Examination Center.Adipokines were divided into quartiles, and metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel-III (NCEP ATP III).A logistic regression model was fitted to establish the association between adipokines and metabolic syndrome.Adipokines, such as adiponectin, HMW adiponectin, and leptin, were found to be statistically related to metabolic syndrome.Compared to the lowest quartile, the leptin/HMW adiponectin ratio in the highest quartile was associated with a 5-fold increase in the probability of prevalent metabolic syndrome, which was independent of age, smoking status, exercise, low-density lipoprotein (LDL) cholesterol, and body mass index.There was a linear increase in the leptin/HMW adiponectin ratio as the number of metabolic syndrome components increased.The leptin/HMW adiponectin ratio had the highest odds ratio in women.In addition, compared to adiponectin or leptin alone, the AUC of the leptin/adiponectin ratio and leptin/HMW adiponectin ratio was higher for metabolic syndrome.We may suggest that the leptin/HMW adiponectin ratio is not superior to other adipokine markers, but is as effective as the leptin/total adiponectin ratio.

【 授权许可】

Unknown