Molecular diagnosis of Pseudoterranova decipiens s.s in human, France

BMC Infectious Diseases

Case Report

Emilie Fréalle¹  Joaquina Martin-Sanchez²  Magdalena Gómez-Mateos²  Gema Merino-Espinosa²  Bernard Pesson³  Jean-Philippe Lemoine³  Ahmed Abou-Bacar⁴  Julie Brunet⁴  Alexander W. Pfaff⁴  Ermanno Candolfi⁴  Hélène Yera⁵  Jean Dupouy-Camet⁵  Maude Royant⁶ 

[1] CHU Lille, Laboratoire de Parasitologie-Mycologie et Université de Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019 – UMR 8204 – CIIL – Center for Infection and Immunity, Lille, France;Departamento de Parasitología, Facultad de Farmacia, Universidad de Granada, Campus Universitario de Cartuja s, /n 18071, Granada, Spain;Laboratoire de Parasitologie et de Mycologie Médicale, Plateau Technique de Microbiologie, Hôpitaux Universitaires de Strasbourg, BP 426, 1 place de l’Hôpital, F-67091, Strasbourg cedex, France;Laboratoire de Parasitologie et de Mycologie Médicale, Plateau Technique de Microbiologie, Hôpitaux Universitaires de Strasbourg, BP 426, 1 place de l’Hôpital, F-67091, Strasbourg cedex, France;Institut de Parasitologie et Pathologie Tropicale, EA 7292, Fédération de Médecine Translationnelle, Université de Strasbourg, 3 rue Koeberlé, F-67000, Strasbourg, France;Service de Parasitologie-Mycologie, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 27 rue du Faubourg St Jacques, F-75015, Paris, France;Service des consultations externes, Hôpitaux Universitaires de Strasbourg, BP 426, 1 place de l’Hôpital, F-67091, Strasbourg cedex, France;

关键词: Pseudoterranova decipiens;    Anisakidae;    Nematode;    Molecular identification;    Human infection;    France;   

DOI  :  10.1186/s12879-017-2493-7

 received in 2016-07-04, accepted in 2017-05-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAnisakis and Pseudoterranova are the main genera involved in human infections caused by nematodes of the Anisakidae family. Species identification is complicated due to the lack of differential morphological characteristics at the larval stage, thus requiring molecular differentiation. Pseudoterranova larvae ingested through raw fish are spontaneously eliminated in most cases, but mechanical removal by means of endoscopy might be required. To date, only very few cases of Pseudoterranova infection have been reported in France.Case presentationA 19-year-old woman from Northeastern France detected, while brushing her teeth, a larva exiting through her mouth. The patient who presented with headache, diarrhea, and abdominal cramps reported having eaten baked cod. The worm was a fourth-stage larva with a size of 22 × 0.9 mm, and molecular biology identified it as Pseudoterranova decipiens sensu stricto (s. s.). In a second P. decipiens infection case, occurring a few months later, a worm exited through the patient’s nose after she had eaten raw sea bream.ConclusionThese two cases demonstrate that Pseudoterranova infection is not uncommon among French patients. Therefore, molecular techniques should be more widely applied for a better characterization of anisakidosis epidemiology in France.

【 授权许可】

CC BY   
© The Author(s). 2017