Cdk5 links with DNA damage response and cancer

Molecular Cancer

Review

Yue Li¹  Jun Li¹  Hai-Dong Zhao¹  Yu-Shu Song¹  Wan Liu¹  Yu-Hong Jia² 

[1] Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Zhongshan Road 467, 116023, Dalian, China;Department of Pathophysiology, Dalian Medical University, Lvshun South Road West 9, 116044, Dalian, China;

关键词: Cyclin dependent kinase 5;    DNA damage response;    Apoptosis;    Cancer;    Targeted cancer therapy;   

DOI  :  10.1186/s12943-017-0611-1

 received in 2016-05-10, accepted in 2017-02-05,  发布年份 2017

来源: Springer

【 摘 要 】

As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post-mitotic neurons. Recent studies show that Cdk5 participates in a series of biological and pathological processes in non-neuronal cells, and is generally dysregulated in various cancer cells. The inhibition or knockdown of Cdk5 has been proven to play an anti-cancer role through various mechanisms, and can synergize the killing effect of chemotherapeutics. DNA damage response (DDR) is a series of regulatory events including DNA damage, cell-cycle arrest, regulation of DNA replication, and repair or bypass of DNA damage to ensure the maintenance of genomic stability and cell viability. Here we describe the regulatory mechanisms of Cdk5, its controversial roles in apoptosis and focus on its links to DDR and cancer.

【 授权许可】

CC BY   
© The Author(s). 2017