Multi-omics analysis of DNA replication-associated primase polymerase (PRIMPOL) in pan-cancer: a potential target for prognosis and immune response

European Journal of Medical Research

Research

Langmei Deng¹  Zhilan Li²  Jinwu Peng³  Liying Song⁴  Abhimanyu Thakur⁵ 

[1] Department of Emergency, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Pathology, Xiangya Changde Hospital, Changde, Hunan, China;Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China;Pritzker School of Molecular Engineering, Ben May, Department for Cancer Research, University of Chicago, Chicago, IL, USA;

关键词: PRIMPOL;    Cancer;    Immune infiltration;    Prognosis;    DNA damage response;   

DOI  :  10.1186/s40001-023-01181-9

 received in 2023-02-08, accepted in 2023-06-21,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIt is critical to understand the mechanisms of human cancers in order to develop the effective anti-cancer therapeutic strategies. Recent studies indicated that primase polymerase (PRIMPOL) is strongly associated with the development of human cancers. Nevertheless, a systematic pan-cancer analysis of PRIMPOL remains to be further clarified.MethodComprehensive multi-omics bioinformatics algorithms, such as TIMER2.0, GEPIA2.0 and cBioPortal, were utilized to evaluate the biological roles of PRIMPOL in pan-cancer, including the expression profiles, genomic alterations, prognostic values and immune regulation.ResultsPRIMPOL was upregulated in glioblastoma multiforme and kidney renal clear cell carcinoma. The brain lower grade glioma patients with enhanced PRIMPOL expression displayed poor prognostic values. We also demonstrated the PRIMPOL's immunomodulating effects on pan-cancer as well as its genomic changes and methylation levels. The aberrant expression of PRIMPOL was linked to various cancer-associated pathways, including DNA damage response, DNA repair, and angiogenesis, according to single-cell sequencing and function enrichment.ConclusionsThis pan-cancer analysis offers a thorough review of the functional roles of PRIMPOL in human cancers, suggesting PRIMPOL as a potentially important biomarker for the progression and immunotherapy of various cancers.

【 授权许可】

CC BY   
© The Author(s) 2023

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