Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

BMC Pediatrics

Research

Amy C. Alman¹  Henian Chen¹  Nathan J. Cohen¹  Russell S. Kirby¹  Ronee Wilson¹  Serena Defina²  Charlotte A.M. Cecil³  Hanan El Marroun⁴  Henning Tiemeier⁵  Kimberly Fryer⁶  Sabrina Faleschini⁷  Sheryl L. Rifas-Shiman⁷  Emily Oken⁸  Marie-France Hivert⁹ 

[1] College of Public Health, University of South Florida, Tampa, FL, USA;Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands;Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Psychology, Education, and Child Studies, Erasmus School of Social and Behavioral Sciences, Rotterdam, The Netherlands;Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA;Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA;Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA;

关键词: Depression;    Glucocorticoids;    Prenatal exposure delayed effects;    Hair;   

DOI  :  10.1186/s12887-023-04372-9

 received in 2023-03-30, accepted in 2023-10-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPrior studies have reported conflicting results regarding the association of prenatal maternal depression with offspring cortisol levels. We examined associations of high levels of prenatal depressive symptoms with child cortisol biomarkers.MethodsIn Project Viva (n = 925, Massachusetts USA), mothers reported their depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy, cord blood glucocorticoids were measured at delivery, and child hair cortisol levels were measured in mid-childhood (mean (SD) age: 7.8 (0.8) years) and early adolescence (mean (SD) age: 13.2 (0.9) years). In the Generation R Study (n = 1644, Rotterdam, The Netherlands), mothers reported depressive symptoms using the Brief Symptom Inventory (BSI) during pregnancy, and child hair cortisol was measured at a mean (SD) age of 6.0 (0.5) years. We used cutoffs of ≥ 13 for the EPDS and > 0.75 for the BSI to indicate high levels of prenatal depressive symptoms. We used multivariable linear regression models adjusted for child sex and age (at outcome), and maternal pre-pregnancy BMI, education, social support from friends/family, pregnancy smoking status, marital status, and household income to assess associations separately in each cohort. We also meta-analyzed childhood hair cortisol results from both cohorts.Results8.0% and 5.1% of women respectively experienced high levels of prenatal depressive symptoms in Project Viva and the Generation R Study. We found no associations between high levels of maternal depressive symptoms during pregnancy and child cortisol biomarkers in either cohort.ConclusionsThe present study does not find support for the direct link between high levels of maternal depressive symptoms and offspring cortisol levels.

【 授权许可】

CC BY   
© The Author(s) 2023

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