Impact of interventions on the quality of life of cancer patients: a systematic review and meta-analysis of longitudinal research

Health and Quality of Life Outcomes

Research

Carl A. Latkin¹  Thanh Thien Le²  Cyrus S.H. Ho³  Roger C.M. Ho⁴  Xuan Thanh Nguyen⁵  Linh Gia Vu⁶  Nam Gia Dao⁶  Duy Cao Nguyen⁶  Long Bao Nguyen⁷  Thuc Minh Thi Vu⁸  Trang Huyen Thi Dang⁸  Melvyn W.B. Zhang⁹  Pascal Auquier^1,10  Laurent Boyer^1,10  Guillaume Fond^1,10 

[1] Bloomberg School of Public Health, Johns Hopkins University, 21205, Baltimore, MD, USA;Department of Biomedical Engineering, Tufts University, 200 College Avenue, 02155, Medford, MA, USA;Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, 119077, Singapore, Singapore;Hue Central General Hospital, 52000, Hue, Vietnam;Institute for Global Health Innovations, Duy Tan University, 550000, Da Nang, Vietnam;Faculty of Medicine, Duy Tan University, 550000, Da Nang, Vietnam;Institute for Preventive Medicine and Public Health, Hanoi Medical University, 100000, Hanoi, Vietnam;Institute of Health Economics and Technology (iHEAT), Hanoi, Vietnam;Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore;Research Centre on Health Services and Quality of Life, Aix Marseille University, 27, boulevard Jean-Moulin, 3279, 13385, CEReSS, Marseille cedex 05, France;

关键词: Quality of life;    HRQL;    Cancer;    Interventions;   

DOI  :  10.1186/s12955-023-02189-9

 received in 2023-03-30, accepted in 2023-09-11,  发布年份 2023

来源: Springer

【 摘 要 】

The impact of cancer interventions has been conducted in several research due to the significant burden of this non-communicable disease. The interventions that played an important role in the improvement of the patient’s quality of life (QoL) and health-related quality of life (HRQL) can be classified into two main groups: pharmaceutical and non-pharmacological methods. However, studies so far often analyze a specific group of interventions for specific types of cancer. Thus, in this systematic review and meta-analysis, we synthesized the overall impact of cancer interventions on patients’ quality of life in several cancers.In this research, we followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) to search the longitudinal original research on the Web of Science (WOS) database. After that, the Newcastle-Ottawa Scale (NOS) and Jadad Scale were used to assess the quality of non-randomized control trials and randomized control trials, respectively. Then, the characteristics of the included studies were described in the six main fields table and the random effect model with robust estimation was applied to analyze the impact of interventions on the health utility of patients.From the database, 122 longitudinal original research were included in the meta-regression, with most of them having high or fair quality. The European Organization for the research and treatment of cancer scale for quality of life (EORTC-QLQ) was the most used health utility measurement at 65.15%. In the adjusted effect models, the Visual Analogue Scale (VAS) had significant statistics in all models when we compared it with the EQ-5D Scale (p < 0.05) and several types of cancer such as breast, lung, and prostate cancer had significant statistics when comparing with hematological cancer in the model types of cancer (p < 0.01). Moreover, radiotherapy, screening, and a combination of chemotherapy and best supportive care also had significant statistics (p < 0.01) in the model of interventions when compared with radiotherapy applied only. Our research can suggest a vital combination of both pharmaceutical and non-pharmacological interventions to improve the quality of life of some common types of cancer patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 1