Phosphorus supplement alters postprandial lipemia of healthy male subjects: a pilot cross-over trial

Lipids in Health and Disease

Short Report

Sani Hlais¹  Maya Bassil²  Jana Hazim³  Hala Ghattas³  Omar Obeid³  Dareen Shatila³ 

[1] Department of Family Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon;Department of Natural Sciences, Faculty of Arts and Sciences, Lebanese American University, Beirut, Lebanon;Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon;

关键词: Phosphorus;    Lipids;    Lipoproteins;    Postprandial lipemia;    ApoB48;    ApoB100;   

DOI  :  10.1186/1476-511X-13-109

 received in 2014-05-21, accepted in 2014-07-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundEpidemiological studies have found a U-shaped relationship between serum phosphorus and cardiovascular disease (CVD). The mechanism(s) behind such a relationship are poorly understood. Phosphorus (P) is reported to improve insulin sensitivity, which is involved in lipid metabolism, and thus we were interested in determining the impact of phosphorus ingestion on postprandial lipemia, a recognized CVD risk factor.FindingsA within–subject study design was conducted, whereby 8 healthy male subjects received a high fat meal (330Kcal; 69% energy from fat; 35 mg of phosphorus) with placebo or phosphorus (500 mg) in a random order. Postprandial blood samples (~10 ml) were collected every hour for 6 hours after meal ingestion. Changes in different parameters were analyzed using a 2-factor repeated-measure ANOVA. In the phosphorus (P) supplemented group, postprandial serum P increased (p = 0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo. Concurrently, phosphorus supplementation increased postprandial concentrations of apolipoprotein B48 (ApoB48) (p < 0.05) and decreased that of apolipoprotein B100 (ApoB100) (p < 0.05).ConclusionsPhosphorus supplementation (500 mg) of the meal seems to alter the different components of postprandial lipemia. These findings highlight the potential role of phosphorus in CVD.

【 授权许可】

Unknown   
© Hazim et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.