Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosispyrazinamidase enzyme and pyrazinamide susceptibility

BMC Genomics

Proceedings

Chakshu Vats¹  Navneeta Bharadvaja¹  Ankita Gupta¹  Sukriti Goyal²  Jaspreet Kaur Dhanjal³  Abhinav Grover³ 

[1] Department of Biotechnology, Delhi Technological University, 110042, New Delhi, India;School of Bioscience and Biotechnology, Banasthali University, 304022, Tonk, Rajasthan, India;School of Biotechnology, Jawaharlal Nehru University, 110067, New Delhi, India;

关键词: Tuberculosis;    Pyrazinamide;    pyrazinamidase;    mutations;    drug resistance;    molecular dynamics simulations;   

DOI  :  10.1186/1471-2164-16-S2-S14

来源: Springer

【 授权许可】

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© Vats et al.; licensee BioMed Central Ltd. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.