Apoptosis, autophagy, necroptosis, and cancer metastasis

Molecular Cancer

Review

Zuozhang Yang¹  Zhenyi Su²  Yongqing Xu³  Yongbin Chen⁴  Qiang Yu⁵ 

[1] Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), 650118, Kunming, Yunnan, China;Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, 650118, Kunming, Yunnan, China;Department of Biochemistry and Molecular Biology, Medical School, Southeast University, 210009, Nanjing, Jiangsu, China;Department of Cell Biology, Harvard Medical School, 02115, Boston, MA, USA;Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, 650118, Kunming, Yunnan, China;Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Shanghai, China;

关键词: Apoptosis;    Autophagy;    Necroptosis;    Metastasis;   

DOI  :  10.1186/s12943-015-0321-5

 received in 2014-12-07, accepted in 2015-02-09,  发布年份 2015

来源: Springer

【 摘 要 】

Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, the development of an inflammatory tumor microenvironment, and defects in programmed cell death. Programmed cell death, such as apoptosis, autophagy, and necroptosis, plays crucial roles in metastatic processes. Malignant tumor cells must overcome these various forms of cell death to metastasize. This review summarizes the recent advances in the understanding of the mechanisms by which key regulators of apoptosis, autophagy, and necroptosis participate in cancer metastasis and discusses the crosstalk between apoptosis, autophagy, and necroptosis involved in the regulation of cancer metastasis.

【 授权许可】

Unknown   
© Su et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.