期刊论文详细信息
BMC Genomics
Reductive evolution in Streptococcus agalactiaeand the emergence of a host adapted lineage
Research Article
Sophie Mangenot1  Barbara Mairey1  Valérie Barbe1  Christophe Rusniok2  Christiane Bouchier3  Laurence Ma3  Elisabeth Sauvage4  Violette Da Cunha4  Isabelle Rosinski-Chupin4  Philippe Glaser4 
[1] CEA/IG/Genoscope, Evry, France;CNRS UMR, 3525, Paris, France;Unité de Biologie des Bactéries Intracellulaires, Institut Pasteur, Paris, France;Genomic Platform, Institut Pasteur, Paris, France;Unité de Biologie des Bactéries Pathogènes à Gram Positif, 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France;CNRS UMR, 3525, Paris, France;
关键词: Streptococcus agalactiae;    Host-adaptation;    Non-homologous recombination;    Gene inactivation;    Virulence;   
DOI  :  10.1186/1471-2164-14-252
 received in 2012-12-31, accepted in 2013-04-01,  发布年份 2013
来源: Springer
PDF
【 摘 要 】

BackgroundDuring host specialization, inactivation of genes whose function is no more required is favored by changes in selective constraints and evolutionary bottlenecks. The Gram positive bacteria Streptococcus agalactiae (also called GBS), responsible for septicemia and meningitis in neonates also emerged during the seventies as a cause of severe epidemics in fish farms. To decipher the genetic basis for the emergence of these highly virulent GBS strains and of their adaptation to fish, we have analyzed the genomic sequence of seven strains isolated from fish and other poikilotherms.ResultsComparative analysis shows that the two groups of GBS strains responsible for fish epidemic diseases are only distantly related. While strains belonging to the clonal complex 7 cannot be distinguished from their human CC7 counterparts according to their gene content, strains belonging to the ST260-261 types probably diverged a long time ago. In this lineage, specialization to the fish host was correlated with a massive gene inactivation and broad changes in gene expression. We took advantage of the low level of sequence divergence between GBS strains and of the emergence of sublineages to reconstruct the different steps involved in this process. Non-homologous recombination was found to have played a major role in the genome erosion.ConclusionsOur results show that the early phase of genome reduction during host specialization mostly involves accumulation of small and likely reversible indels, followed by a second evolutionary step marked by a higher frequency of large deletions.

【 授权许可】

CC BY   
© Rosinski-Chupin et al.; licensee BioMed Central Ltd. 2013

【 预 览 】
附件列表
Files Size Format View
RO202311101567784ZK.pdf 1426KB PDF download
【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
  • [32]
  • [33]
  • [34]
  • [35]
  • [36]
  • [37]
  • [38]
  • [39]
  • [40]
  • [41]
  • [42]
  • [43]
  • [44]
  • [45]
  • [46]
  • [47]
  • [48]
  • [49]
  • [50]
  • [51]
  • [52]
  • [53]
  • [54]
  • [55]
  • [56]
  • [57]
  • [58]
  • [59]
  • [60]
  • [61]
  • [62]
  • [63]
  • [64]
  • [65]
  • [66]
  • [67]
  • [68]
  • [69]
  • [70]
  • [71]
  • [72]
  • [73]
  • [74]
  • [75]
  • [76]
  • [77]
  • [78]
  • [79]
  • [80]
  • [81]
  • [82]
  • [83]
  • [84]
  • [85]
  文献评价指标  
  下载次数:6次 浏览次数:1次