National age group trends in Clostridium difficile infection incidence and health outcomes in United States Community Hospitals

BMC Infectious Diseases

Research Article

Ashley Pechal¹  Stefan Allen¹  Kelly Reveles¹  Kevin Lin¹ 

[1] College of Pharmacy, The University of Texas at Austin, 7703 Floyd Curl Drive, MC-6220, 78229, San Antonio, TX, USA;Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-6220, 78229, San Antonio, TX, USA;

关键词: Clostridium difficile;    Trends;    Incidence;    Hospitals;    Age group;   

DOI  :  10.1186/s12879-016-2027-8

 received in 2016-03-04, accepted in 2016-11-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPrior studies have demonstrated an increase in Clostridium difficile infection (CDI) incidence in the United States (U.S.) in recent years, but trends among different age groups have not been evaluated. This study describes national CDI incidence by age group over a 10-year period and mortality and hospital length of stay (LOS) among patients with CDI.MethodsThis was a retrospective analysis of the U.S. National Hospital Discharge Surveys from 2001 to 2010. Eligible patients with an ICD-9-CM discharge diagnosis code for CDI (008.45) were stratified by age: <18 years (pediatrics), 18–64 years (adults), and  ≥65 years (elderly adults). Data weights were used to derive national estimates. CDI incidence was calculated as CDI discharges/1000 total discharges. Mortality and LOS were compared between age groups using chi-square or Wilcoxon rank sum tests.ResultsThese data represent 2.3 million hospital discharges for CDI over the study period. CDI incidence was highest among elderly adults (11.6 CDI discharges/1000 total discharges), followed by adults (3.5 CDI discharges/1000 total discharges) and pediatrics (1.2 CDI discharges/1000 total discharges). The elderly also had higher rates of mortality (8.8%) compared to adults (3.1%) and pediatrics (1.4%) (p < 0.0001). In addition, median hospital LOS was highest in the elderly (8 days) compared to adults (7 days) and pediatrics (6 days) (p < 0.0001).ConclusionsCDI incidence among patients hospitalized in U.S. hospitals differed based on age group between 2001 and 2010. CDI incidence, mortality, and hospital LOS were highest in the elderly adult population.

【 授权许可】

CC BY   
© The Author(s). 2016