Occupational exposure to wood dust and risk of lung cancer in two population-based case–control studies in Montreal, Canada

Environmental Health

Research

Javier Pintos¹  Jack Siemiatycki²  Marie-Elise Parent³  Eric Vallières³ 

[1] CHUM Research Center, Université de Montréal, Montréal, QC, Canada;CHUM Research Center, Université de Montréal, Montréal, QC, Canada;Department of Social and Preventive Medicine, University of Montreal, Montreal, QC, Canada;INRS – Armand-Frappier Institute, Université du Québec, Laval, QC, Canada;CHUM Research Center, Université de Montréal, Montréal, QC, Canada;Department of Social and Preventive Medicine, University of Montreal, Montreal, QC, Canada;

关键词: Wood dust;    Lung cancer;    Epidemiology;    Case–control studies;    Occupational exposure;    Tobacco;   

DOI  :  10.1186/1476-069X-14-1

 received in 2014-10-08, accepted in 2014-12-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundWood dust is one of the oldest and one of the most common occupational exposures in the world. The present analyses examine the effect of lifetime exposure to wood dust in diverse occupational settings on lung cancer risk.MethodsWe conducted two population-based case–control studies in Montreal: Study I (1979–1986) included 857 cases and two sets of controls (533 population and 1349 cancer controls), and Study II (1996–2001) comprised 736 cases and 894 population controls. Detailed job histories were obtained by interview and each job was evaluated by expert chemist–hygienists to estimate the likelihood and level of exposure to many substances, one of which was wood dust. Odds ratios (ORs) were computed in relation to different indices of exposure to wood dust, adjusting for several covariates including smoking. Three datasets were analysed: Study I with population controls, Study I with cancer controls, and Study II.ResultsThe most frequently exposed occupations in our study population were in construction, timber and furniture making industries. We found increased risks of lung cancer for substantial cumulative exposure to wood dust in Study I with cancer controls, (OR = 1.4: 95% confidence interval 1.0;-2.0) and in Study II (OR = 1.7: 95% confidence interval 1.1-2.7). There were no excess risks of lung cancer in any of the three datasets among workers whose cumulative exposure was not substantial. These tendencies held equally within strata of low smokers and heavy smokers.ConclusionThere was evidence of increased risk of lung cancer among workers with substantial cumulative exposure to wood dust.

【 授权许可】

Unknown   
© Vallières et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.