期刊论文详细信息
Journal of Occupational Medicine and Toxicology
Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde
Roberto Bono1  Federica Ghelli1  Giulia Squillacioti1  Martina Buglisi1  Valeria Bellisario1  Giacomo Garzaro2  Enrico Bergamaschi2  Elena Grignani3 
[1] Department of Public Health and Pediatrics, University of Turin, via Santena 5 bis, 10126, Turin, Italy;Department of Public Health and Pediatrics, University of Turin, via Zuretti 29, 10126, Turin, Italy;Maugeri Scientific Clinical Institutes, Via Salvatore Maugeri, 10, 27100, Pavia, Italy;
关键词: Occupational hygiene;    Biomonitoring;    Epidemiology;    Formaldehyde;    Wood dust;   
DOI  :  10.1186/s12995-021-00293-4
来源: Springer
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【 摘 要 】

BackgroundMany workers are exposed to wood dust (WD) and formaldehyde (FA), whose carcinogenic activity is supposed to be oxidative stress-mediated. This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS induction in a woodworkers’ population.MethodsThe sample population consisted of 127 woodworkers from 4 factories and 111 unexposed controls. Individual exposure was assessed by personal air-samplers. Each participant enrolled in the study filled out a questionnaire and provided a urinary sample to quantify OS biomarkers, namely 15-F2t-IsoProstane (15-F2t-IsoP) and 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo). The main confounding factor for OS, i.e. tobacco smoking exposure, was assessed by measuring cotinine in urine samples.ResultsWoodworkers were exposed to significantly higher amounts of WD and FA as compared to controls (p < 0.001). Among OS biomarkers, 15-F2t-IsoP showed statistically significant higher values in woodworkers compared to controls (p = 0.004). A significant, positive correlation was observed between 15-F2t-IsoP and 8-oxo-dGuo (p = 0.005), cotinine (p = 0.05), FA (p < 0.001) and WD (p = 0.01); 8-oxo-dGuo was significantly correlated with cotinine (p = 0.001) and WD (p = 0.004). In addition, WD and FA were significantly correlated each other (p < 0.001).ConclusionsThe study confirms that WD and FA may induce OS in woodworkers, and highlights that even the compliance with occupational exposure limits can result in measurable biological outcomes.

【 授权许可】

CC BY   

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