Efficacy of frog skin lipids in wound healing

Lipids in Health and Disease

Research

Korrapati Purna Sai¹  Mary Babu¹  Rama Rajaram¹  Venkat Raghavan K¹ 

[1] Department of Biomaterials, Central Leather Research Institute, Chennai, India;

关键词: Wound Healing;    Lipid Extract;    Hydroxyproline;    Uronic Acid;    Polysorbate;   

DOI  :  10.1186/1476-511X-9-74

 received in 2010-06-04, accepted in 2010-07-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundFrog skin has been sequentially and scientifically evaluated by our group for its wound healing efficiency. Owing to the complex structure of skin, attempts were being made to analyse the role of individual constituents in different phases of healing. Our earlier papers have shown the significance of frog skin not only in wound healing but also enhancing the proliferating activity of the epidermal and dermal cells which are instrumental for normal healing process. We also have identified for the first time novel antimicrobial peptides from the skin of Rana tigerina and thereby reduce the complications involved in the sepsis.Purpose of the study and ResultsThe current study envisages the role of frog skin lipids in the inflammatory phase of wound healing. The lipid moiety of the frog skin dominated by phospholipids exhibited a dose dependent acceleration of healing irrespective of the mode of application. The efficiency of the extract is attributed partially to the anti-inflammatory activity as observed by the histochemical and immunostimulatory together with plethysmographic studies.ConclusionsThus, frog skin for the first time has been demonstrated to possess lipid components with pharmaceutical and therapeutic potential. The identification and characterization of such natural healing molecules and evaluating their mechanism of action would therefore provide basis for understanding the cues of Nature and hence can be used for application in medicine.

【 授权许可】

Unknown   
© Raghavan K et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.