Intestinal healing in rats submitted to ethanol ingestion

Acta Cirurgica Brasileira

Rodrigo Severo De Camargo Pereira²  Cláudia Nishida Hasimoto²  Leonardo Pelafsky²  Juan Carlos Llanos¹  Daniele Cristina Cataneo²  César Tadeu Spadella²  José Guilherme Minossi² 

[1] ,UNESP Botucatu School of Medicine Surgery and Orthopedics Department,Brazil

关键词: Wound Healing;    Alcoholism;    Ethanol;    Tensile Strenght;    Hydroxyproline;    Rats;    Cicatrização;    Alcoolismo;    Etanol;    Resistência à Tração;    Hidroxiprolina;    Ratos;   

DOI  :  10.1590/S0102-86502012000300006

来源: SciELO

【 摘 要 】

PURPOSE: To study the effect of alcoholism on intestinal healing and postoperative complications in rats METHODS: One hundred and sixty rats were divided into two groups: control and treated. The control group received water and the treated group 30% ethanol. After 180 days, colotomy with anastomosis were performed. After, the groups were divided into four subgroups: 20 rats for study at the following moments: 4th, 7th, 14th and 21st postoperative. The analyzed parameters were: weight gain, breaking strength, tissue hydroxyproline, postoperative complications and histopathological study RESULTS: Weight gain was greater in the control group (p<0.05). When all the subgroups were clustered, breaking strength was significantly greater in the control (p<0.05). Histopathology and hydroxyproline dosage did not show differences. There were five surgical site infections in the treated group while the control group showed two (p>0.05). Nine fistulas occurred in the treated group whereas the control group two (p<0.05). There were three deaths in the control group and seven in the treated group (p>0.05). CONCLUSIONS: Treated group undergo a malnutrition process that is revealed by lower weight gain. Impaired intestinal healing as indicated by smaller breaking strength. There were a larger number of postoperative complications in the treated animals.

【 授权许可】

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