Journal of Cardiovascular Magnetic Resonance | |
Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia | |
Research | |
Felix W Wehrli1  Michael C Langham1  | |
[1] Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA; | |
关键词: Cardiovascular Magnetic Resonance; Blood Flow Velocity; Vascular Reactivity; Reactive Hyperemia; Cardiovascular Magnetic Resonance Protocol; | |
DOI : 10.1186/1532-429X-13-66 | |
received in 2011-07-11, accepted in 2011-10-28, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundPost-occlusive hyperemia is often used as a paradigm to evaluate vascular reactivity, for example by measuring post-ischemic flow-mediated dilation, arterial blood flow or temporally resolved venous blood oxygenation (HbO2). Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure.MethodsA multi-echo GRE pulse sequence was designed and implemented to collect velocity-encoded projections in addition to full-image echoes for field mapping as a means to quantify intravascular magnetic susceptibility. The method's feasibility was evaluated at 3T in a small pilot study involving two groups of healthy subjects (mean ages 26 ± 1.6 and 59 ± 7.3 years, N = 7 and 5, respectively) in terms of six parameters characterizing the time-course of reactive hyperemia and their sensitivity to differentiate age effects. The reproducibility was assessed on two of the seven young healthy subjects with three repeated measurements.ResultsThe physiological parameters agree with those obtained with current methods that quantify either velocity or HbO2 alone. Of the six measures of vascular reactivity, one from each group was significantly different in the two subject groups (p < 0.05) even though the study was not powered to detect differences. The mean coefficient of variation (CV) from two subjects undergoing repeat scans were approximately 8% for the oximetric and the arterial velocimetric parameters in the femoral vein and artery, respectively, considerably below intersubject CVs (20 and 35%, for the young and older subject groups, respectively).ConclusionThe proposed method is able quantify multiple parameters that may lead to more detailed assessment of peripheral vascular reactivity in a single cuff paradigm rather than in separate procedures as required previously, thereby improving measurement efficiency and patient comfort.
【 授权许可】
CC BY
© Langham and Wehrli; licensee BioMed Central Ltd. 2011
【 预 览 】
Files | Size | Format | View |
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RO202311101465274ZK.pdf | 959KB | download |
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