Autonomous control of cardiovascular reactivity in patients with episodic and chronic forms of migraine

The Journal of Headache and Pain

Research Article

Oleg V. Mamontov¹  Alexei A. Kamshilin²  Rashid Giniatullin³  Laura Babayan⁴  Alexander V. Amelin⁴ 

[1] Almazov Federal Heart, Blood and Endocrinology Centre, St. Petersburg, Russia;Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia;Department of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia;Department of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia;Department of Neurobiology, University of Eastern Finland, Kuopio, Finland;Kazan Federal University, Kazan, Russia;Department of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia;Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia;Department of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia;

关键词: Migraine;    Cold Stress;    Chronic Migraine;    Valsalva Maneuver;    Vascular Reactivity;   

DOI  :  10.1186/s10194-016-0645-6

 received in 2016-03-13, accepted in 2016-05-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe autonomous cardiovascular control can contribute to progression of migraine. However, current data on cardiovascular reactivity in migraine, especially severe forms, are essentially contradictory. The main aim of this study was to compare the autonomous regulation of circulation in patients with episodic and chronic migraine and healthy subjects.MethodsSeventy three migraine patients (mean age 35 ± 10) including episodic migraine (51 patients, 4–14 headache days/months) and chronic migraine (22 patients, ≥15 headache days/month) along with age-match control (71 healthy voluntaries) were examined. The autonomic regulation of circulation was examined with the tilt-table test, a deep breathing and Valsalva Maneuver, handgrip test, cold-stress vasoconstriction, arterial baroreflex and blood pressure variability.ResultsThe changes in heart rate induced by deep breathing, Valsalva Maneuver, and blood pressure in tilt-table test in patients with migraine did not differ from the control group. In contrast, the values of cold-stress-vasoconstriction forearm blood-flow reactivity (p <0.001), the increase in diastolic blood pressure in handgrip test (p <0.001), mean blood pressure in the late stage of the second phase of Valsalva Maneuver (p <0.001) and blood pressure variability (p <0.005) were all higher in patients with migraine than in the control group.ConclusionThus, both episodic and chronic migraine are associated with significant disturbances in autonomous control resulting in enhanced vascular reactivity whereas the cardiac regulation remains largely unchanged.

【 授权许可】

CC BY   
© Mamontov et al. 2016