The impact of fetal gender on prematurity in dichorionic twin gestations after in vitro fertilization

Reproductive Biology and Endocrinology

Debate

Katharina Klein¹  Christof Worda¹  Maria Stammler-Safar¹  Peter Husslein¹  Andrea Weghofer²  David H Barad³  Norbert Gleicher⁴ 

[1] Department of Obstetrics & Gynecology, Medical University Vienna, Vienna, Austria;Department of Obstetrics & Gynecology, Medical University Vienna, Vienna, Austria;The Center for Human Reproduction and The Foundation for Reproductive Medicine, New York, New York, USA;The Center for Human Reproduction and The Foundation for Reproductive Medicine, New York, New York, USA;The Center for Human Reproduction and The Foundation for Reproductive Medicine, New York, New York, USA;Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine,, New Haven, Connecticut, USA;

关键词: Preterm Birth;    Assisted Reproductive Technology;    Twin Pregnancy;    Assist Reproduction Technology;    Twin Gestation;   

DOI  :  10.1186/1477-7827-8-57

 received in 2010-03-25, accepted in 2010-06-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundImpact of fetal gender on prematurity has been primarily investigated in singleton pregnancies. In an attempt to understand better how fetal gender may affect gestational length in twin gestations after in vitro fertilization, same-sex twins and opposite twins were compared for pregnancy duration.MethodsThis study evaluated 113 women at ages 20 to 39 years with consecutive dichorionic-diamniotic twin gestations after assisted reproduction. All pregnancies were results of fresh in vitro fertilization (IVF) cycles with use of autologous oocytes and sperm and were delivered at up to 37 weeks of gestation at a University-based high-risk, maternal-fetal medicine unit.ResultsBoth groups did not differ in baseline characteristics, such as maternal ages, indications for fertility treatments, number of previous IVF attempts, body mass index and parity. Opposite sex- twins, however, presented with significantly shorter gestational age at birth (32.9 +/- 3.4 weeks) than same-sex twins (34.3 +/- 2.5 weeks), (p < 0.05). Younger maternal age was also associated with shorter pregnancy duration (p < 0.05).ConclusionsFetal gender mix serves as risk factor for more significant prematurity in dichorionic-diamniotic twins after assisted reproduction with opposite sex twins at higher risk than same sex-twins.

【 授权许可】

CC BY   
© Weghofer et al; licensee BioMed Central Ltd. 2010