SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation

Lipids in Health and Disease

Research

Iwona Rudkowska¹  Simone Lemieux²  Annie Bouchard-Mercier³  Marie-Claude Vohl³  Louis Pérusse⁴  Patrick Couture⁵ 

[1] Endocrinology and Nephrology, CHU de Québec Research Center, 2705 Laurier Blvd., G1V 4G2, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., G1V 0A6, Quebec, Canada;Department of Food Science and Nutrition, Laval University, 2425 de l’Agriculture St., G1K 7P4, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., G1V 0A6, Quebec, Canada;Department of Food Science and Nutrition, Laval University, 2425 de l’Agriculture St., G1K 7P4, Quebec, Canada;Endocrinology and Nephrology, CHU de Québec Research Center, 2705 Laurier Blvd., G1V 4G2, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., G1V 0A6, Quebec, Canada;Department of Kinesiology, Laval University, G1K 7P4, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., G1V 0A6, Quebec, Canada;Endocrinology and Nephrology, CHU de Québec Research Center, 2705 Laurier Blvd., G1V 4G2, Quebec, Canada;

关键词: SREBF1;    Fish oil supplementation;    Insulin sensitivity;    Inter-individual variability;    Polymorphisms;   

DOI  :  10.1186/1476-511X-13-152

 received in 2014-08-07, accepted in 2014-09-27,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAn important inter-individual variability in the response of insulin sensitivity following a fish oil supplementation has been observed. The objective was to examine the associations between single nucleotide polymorphisms (SNPs) within sterol regulatory element binding transcription factor 1 (SREBF1) gene and the response of insulin sensitivity to a fish oil supplementation.MethodsParticipants (n = 210) were recruited in the greater Quebec City area and followed a 6-week fish oil supplementation protocol (5 g/day: 1.9-2.2 g EPA; 1.1 g DHA). Insulin sensitivity was assessed by the quantitative insulin sensitivity check index (QUICKI). Three tag SNPs (tSNPs) within SREBF1 gene were genotyped according to TAQMAN methodology.ResultsThree tSNPs (rs12953299, rs4925118 and rs4925115) covered 100% of the known genetic variability within SREBF1 gene. None of the three tSNPs was associated with either baseline fasting insulin concentrations (rs12953299, rs4925118 and rs4925115) (p = 0.29, p = 0.20 and p = 0.70, respectively) or QUICKI (p = 0.20, p = 0.18 and p = 0.76, respectively). The three tSNPs (rs12953299, rs4925118 and rs4925115) were associated with differences in the response of plasma insulin levels (p = 0.01, p = 0.005 and p = 0.004, respectively) and rs12953299 as well as rs4925115 were associated with the insulin sensitivity response (p = 0.009 and p = 0.01, respectively) to the fish oil supplementation, independently of the effects of age, sex and BMI.ConclusionsThe genetic variability within SREBF1 gene has an impact on the insulin sensitivity in response to a fish oil supplementation.Trial registrationclinicaltrials.gov: NCT01343342.

【 授权许可】

Unknown   
© Bouchard-Mercier et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.