SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation

Lipids in Health and Disease

Marie-Claude Vohl³  Louis Pérusse¹  Patrick Couture³  Simone Lemieux²  Iwona Rudkowska³  Annie Bouchard-Mercier³ 

[1] Department of Kinesiology, Laval University, Quebec G1K 7P4, Canada;Department of Food Science and Nutrition, Laval University, 2425 de l’Agriculture St., Quebec G1K 7P4, Canada;Endocrinology and Nephrology, CHU de Québec Research Center, 2705 Laurier Blvd., Quebec G1V 4G2, Canada

关键词: Polymorphisms;    Inter-individual variability;    Insulin sensitivity;    Fish oil supplementation;    SREBF1 gene;   

Others  :  1152044
DOI  :  10.1186/1476-511X-13-152

 received in 2014-08-07, accepted in 2014-09-27,  发布年份 2014

【 摘 要 】

Background

An important inter-individual variability in the response of insulin sensitivity following a fish oil supplementation has been observed. The objective was to examine the associations between single nucleotide polymorphisms (SNPs) within sterol regulatory element binding transcription factor 1 (SREBF1) gene and the response of insulin sensitivity to a fish oil supplementation.

Methods

Participants (n = 210) were recruited in the greater Quebec City area and followed a 6-week fish oil supplementation protocol (5 g/day: 1.9-2.2 g EPA; 1.1 g DHA). Insulin sensitivity was assessed by the quantitative insulin sensitivity check index (QUICKI). Three tag SNPs (tSNPs) within SREBF1 gene were genotyped according to TAQMAN methodology.

Results

Three tSNPs (rs12953299, rs4925118 and rs4925115) covered 100% of the known genetic variability within SREBF1 gene. None of the three tSNPs was associated with either baseline fasting insulin concentrations (rs12953299, rs4925118 and rs4925115) (p = 0.29, p = 0.20 and p = 0.70, respectively) or QUICKI (p = 0.20, p = 0.18 and p = 0.76, respectively). The three tSNPs (rs12953299, rs4925118 and rs4925115) were associated with differences in the response of plasma insulin levels (p = 0.01, p = 0.005 and p = 0.004, respectively) and rs12953299 as well as rs4925115 were associated with the insulin sensitivity response (p = 0.009 and p = 0.01, respectively) to the fish oil supplementation, independently of the effects of age, sex and BMI.

Conclusions

The genetic variability within SREBF1 gene has an impact on the insulin sensitivity in response to a fish oil supplementation.

Trial registration

clinicaltrials.gov: NCT01343342.

【 授权许可】

   
2014 Bouchard-Mercier et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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