Streptococcus agalactiae in adults at chiang mai university hospital: a retrospective study

BMC Infectious Diseases

Research Article

Thira Sirisanthana¹  Romanee Chaiwarith¹  Khuanchai Supparatpinyo¹  Waree Jullaket¹  Nontakan Nuntachit¹  Manasanant Bunchoo¹ 

[1] Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;

关键词: Meningitis;    Vancomycin;    Bloodstream Infection;    Spontaneous Bacterial Peritonitis;    Joint Fluid;   

DOI  :  10.1186/1471-2334-11-149

 received in 2010-12-30, accepted in 2011-05-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundInfection caused by Streptococcus agalactiae, a Group B streptococcus, is an emerging disease in non-pregnant adults. This study describes the epidemiological, clinical, and microbiological characteristics of S. agalactiae infection in adult patients in northern Thailand.MethodsA retrospective study was conducted between January 1, 2006 and December 31, 2009 at Chiang Mai University Hospital among patients aged ≥15 years, whose clinical specimens obtained from normally sterile sites grew S. agalactiae.ResultsOne-hundred and eighty-six patients and 197 specimens were identified during the 4-year period. Among 186 patients, 82 were documented as having invasive infection; 42 patients were male (51.2%) with the mean age of 48.5 ± 19.4 years (range 17, 83). Fifty-three patients (64.6%) had underlying medical conditions; 17 patients (20.7%), 10 (12.2%), 8 (9.7%) had diabetes, chronic renal diseases, and malignancy, respectively. Among 40 patients (48.8%) with bloodstream infection, no other site of infection was determined in 29 (35.4%) patients. In the remaining 11 patients, 5 patients (6.1%), 5 (6.1%), and 1 (1.2%) had meningitis, arthritis, and meningitis with arthritis, respectively. Forty-two patients (51.2%) presented with localized infection, i.e., subcutaneous abscess (19 patients, 23.2%), chorioamnionitis (10 patients, 12.2%), urinary tract infection (5 patients, 6.1%), arthritis (3 patients, 3.7%), meningitis (2 patients, 2.4%), and spontaneous bacterial peritonitis, uveitis, and tracheobronchitis (1 patient each, 1.2%). The overall mortality was 14.6% (12 patients).ConclusionsS. agalactiae infection is a growing problem in non-pregnant patients, particularly in those with underlying medical conditions. Physicians should add S. agalactiae infection in the list of differential diagnoses in patients with meningitis and/or septicemia.

【 授权许可】

CC BY   
© Chaiwarith et al; licensee BioMed Central Ltd. 2011